Metastatic squamous cell carcinoma of known and unknown primary origin treated with axillary or inguinal lymphadenectomy

Michael M. Wach, Elke van Beek, Reed Ayabe, Samantha Ruff, Zachary Brown, Debra A. Goldman, Constantinos P. Zambirinis, Sepideh Gholami, Melissa Pulitzer, Jonathan Hernandez, Daniel Coit

Research output: Contribution to journalArticle

Abstract

Background: Metastatic squamous cell carcinoma (SCC) to the axillary or inguinal lymph nodes from an unknown primary source is rarely encountered. We sought to evaluate a cohort of patients with metastatic SCC managed by lymphadenectomy to determine their survival and to determine which clinicopathologic factors were associated with outcome. Methods: All patients undergoing axillary or inguinal lymphadenectomy for SCC at our institution were identified retrospectively. Patients were stratified by unknown primary (UP) vs known skin primary (KP) tumors. Pertinent data on patient, tumor, and treatment variables was collected. Results: We identified 51 patients who met inclusion criteria. Of those, 20 patients (39%) had UP metastatic SCC and 31 patients (61%) had KP. The 5-year overall survival for UP was 65%, as compared to 49% for KP (p = 0.16). Cumulative incidence of recurrence was 46%. Cox regression failed to demonstrate a significant association between KP vs UP, HPV status, chemotherapy, or radiation with survival. Conclusions: Nearly two-thirds of patients undergoing axillary or inguinal lymphadenectomy for metastatic SCC of unknown primary were alive five years following the procedure.

Original languageEnglish (US)
JournalAmerican Journal of Surgery
DOIs
StateAccepted/In press - Jan 1 2018
Externally publishedYes

Fingerprint

Groin
Lymph Node Excision
Squamous Cell Carcinoma
Skin
Survival
Neoplasms
Lymph Nodes
Radiation
Recurrence
Drug Therapy
Incidence

ASJC Scopus subject areas

  • Surgery

Cite this

Metastatic squamous cell carcinoma of known and unknown primary origin treated with axillary or inguinal lymphadenectomy. / Wach, Michael M.; van Beek, Elke; Ayabe, Reed; Ruff, Samantha; Brown, Zachary; Goldman, Debra A.; Zambirinis, Constantinos P.; Gholami, Sepideh; Pulitzer, Melissa; Hernandez, Jonathan; Coit, Daniel.

In: American Journal of Surgery, 01.01.2018.

Research output: Contribution to journalArticle

Wach, Michael M. ; van Beek, Elke ; Ayabe, Reed ; Ruff, Samantha ; Brown, Zachary ; Goldman, Debra A. ; Zambirinis, Constantinos P. ; Gholami, Sepideh ; Pulitzer, Melissa ; Hernandez, Jonathan ; Coit, Daniel. / Metastatic squamous cell carcinoma of known and unknown primary origin treated with axillary or inguinal lymphadenectomy. In: American Journal of Surgery. 2018.
@article{327d498ad51e4752b2aede0c1ac188b5,
title = "Metastatic squamous cell carcinoma of known and unknown primary origin treated with axillary or inguinal lymphadenectomy",
abstract = "Background: Metastatic squamous cell carcinoma (SCC) to the axillary or inguinal lymph nodes from an unknown primary source is rarely encountered. We sought to evaluate a cohort of patients with metastatic SCC managed by lymphadenectomy to determine their survival and to determine which clinicopathologic factors were associated with outcome. Methods: All patients undergoing axillary or inguinal lymphadenectomy for SCC at our institution were identified retrospectively. Patients were stratified by unknown primary (UP) vs known skin primary (KP) tumors. Pertinent data on patient, tumor, and treatment variables was collected. Results: We identified 51 patients who met inclusion criteria. Of those, 20 patients (39{\%}) had UP metastatic SCC and 31 patients (61{\%}) had KP. The 5-year overall survival for UP was 65{\%}, as compared to 49{\%} for KP (p = 0.16). Cumulative incidence of recurrence was 46{\%}. Cox regression failed to demonstrate a significant association between KP vs UP, HPV status, chemotherapy, or radiation with survival. Conclusions: Nearly two-thirds of patients undergoing axillary or inguinal lymphadenectomy for metastatic SCC of unknown primary were alive five years following the procedure.",
author = "Wach, {Michael M.} and {van Beek}, Elke and Reed Ayabe and Samantha Ruff and Zachary Brown and Goldman, {Debra A.} and Zambirinis, {Constantinos P.} and Sepideh Gholami and Melissa Pulitzer and Jonathan Hernandez and Daniel Coit",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.amjsurg.2018.06.006",
language = "English (US)",
journal = "American Journal of Surgery",
issn = "0002-9610",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Metastatic squamous cell carcinoma of known and unknown primary origin treated with axillary or inguinal lymphadenectomy

AU - Wach, Michael M.

AU - van Beek, Elke

AU - Ayabe, Reed

AU - Ruff, Samantha

AU - Brown, Zachary

AU - Goldman, Debra A.

AU - Zambirinis, Constantinos P.

AU - Gholami, Sepideh

AU - Pulitzer, Melissa

AU - Hernandez, Jonathan

AU - Coit, Daniel

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: Metastatic squamous cell carcinoma (SCC) to the axillary or inguinal lymph nodes from an unknown primary source is rarely encountered. We sought to evaluate a cohort of patients with metastatic SCC managed by lymphadenectomy to determine their survival and to determine which clinicopathologic factors were associated with outcome. Methods: All patients undergoing axillary or inguinal lymphadenectomy for SCC at our institution were identified retrospectively. Patients were stratified by unknown primary (UP) vs known skin primary (KP) tumors. Pertinent data on patient, tumor, and treatment variables was collected. Results: We identified 51 patients who met inclusion criteria. Of those, 20 patients (39%) had UP metastatic SCC and 31 patients (61%) had KP. The 5-year overall survival for UP was 65%, as compared to 49% for KP (p = 0.16). Cumulative incidence of recurrence was 46%. Cox regression failed to demonstrate a significant association between KP vs UP, HPV status, chemotherapy, or radiation with survival. Conclusions: Nearly two-thirds of patients undergoing axillary or inguinal lymphadenectomy for metastatic SCC of unknown primary were alive five years following the procedure.

AB - Background: Metastatic squamous cell carcinoma (SCC) to the axillary or inguinal lymph nodes from an unknown primary source is rarely encountered. We sought to evaluate a cohort of patients with metastatic SCC managed by lymphadenectomy to determine their survival and to determine which clinicopathologic factors were associated with outcome. Methods: All patients undergoing axillary or inguinal lymphadenectomy for SCC at our institution were identified retrospectively. Patients were stratified by unknown primary (UP) vs known skin primary (KP) tumors. Pertinent data on patient, tumor, and treatment variables was collected. Results: We identified 51 patients who met inclusion criteria. Of those, 20 patients (39%) had UP metastatic SCC and 31 patients (61%) had KP. The 5-year overall survival for UP was 65%, as compared to 49% for KP (p = 0.16). Cumulative incidence of recurrence was 46%. Cox regression failed to demonstrate a significant association between KP vs UP, HPV status, chemotherapy, or radiation with survival. Conclusions: Nearly two-thirds of patients undergoing axillary or inguinal lymphadenectomy for metastatic SCC of unknown primary were alive five years following the procedure.

UR - http://www.scopus.com/inward/record.url?scp=85051720322&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85051720322&partnerID=8YFLogxK

U2 - 10.1016/j.amjsurg.2018.06.006

DO - 10.1016/j.amjsurg.2018.06.006

M3 - Article

C2 - 30143231

AN - SCOPUS:85051720322

JO - American Journal of Surgery

JF - American Journal of Surgery

SN - 0002-9610

ER -