Metastatic head and neck cancer: Role and usefulness of FDG PET in locating occult primary tumors

O. Sami Aassar, Nancy J. Fischbein, Gary R Caputo, Michael J. Kaplan, David C. Prince, Mark I. Singer, William P. Dillon, Randall A. Hawkins

Research output: Contribution to journalArticle

160 Citations (Scopus)

Abstract

PURPOSE: To assess the usefulness of 2-[fluorine-18]fluoro-2-deoxy-D- glucose (FDG) positron emission tomography (PET) of the head and neck in locating occult primary lesions in patients with metastatic cervical adenopathy. MATERIALS AND METHODS: Seventeen patients with metastatic cervical adenopathy of unknown primary origin were referred for FDG PET of the head and neck. All patients had undergone correlative anatomic imaging within 1 month of FDG PET. Surgical, clinical, and histopathologic findings were used to assess the performance of FDG PET. RESULTS: Increased apical lung uptake at FDG PET led to a biopsy-proved diagnosis of primary lung cancer in two patients. Of the remaining 15 patients, 10 had a focus of increased activity; directed biopsy of these sites led to confirmation of a primary carcinoma in seven patients. Correlative anatomic imaging failed to demonstrate the primary sites of disease in two of these seven patients. None of the five patients with negative FDG PET studies have manifested evidence of a primary site of disease during follow-up of 8-42 months (mean, 29 months). CONCLUSION: FDG PET allows effective localization of the unknown primary site of origin in metastatic head and neck cancer and can contribute substantially to patient care.

Original languageEnglish (US)
Pages (from-to)177-181
Number of pages5
JournalRadiology
Volume210
Issue number1
StatePublished - Jan 1999

Fingerprint

Fluorine
Deoxyglucose
Head and Neck Neoplasms
Positron-Emission Tomography
Neoplasms
Neck
Head
Biopsy
Lung Neoplasms
Patient Care
Carcinoma
Lung

Keywords

  • Fluorine
  • Head and neck neoplasms, diagnosis
  • Head and neck neoplasms, emission CT (ECT)
  • Head and neck neoplasms, secondary

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Aassar, O. S., Fischbein, N. J., Caputo, G. R., Kaplan, M. J., Prince, D. C., Singer, M. I., ... Hawkins, R. A. (1999). Metastatic head and neck cancer: Role and usefulness of FDG PET in locating occult primary tumors. Radiology, 210(1), 177-181.

Metastatic head and neck cancer : Role and usefulness of FDG PET in locating occult primary tumors. / Aassar, O. Sami; Fischbein, Nancy J.; Caputo, Gary R; Kaplan, Michael J.; Prince, David C.; Singer, Mark I.; Dillon, William P.; Hawkins, Randall A.

In: Radiology, Vol. 210, No. 1, 01.1999, p. 177-181.

Research output: Contribution to journalArticle

Aassar, OS, Fischbein, NJ, Caputo, GR, Kaplan, MJ, Prince, DC, Singer, MI, Dillon, WP & Hawkins, RA 1999, 'Metastatic head and neck cancer: Role and usefulness of FDG PET in locating occult primary tumors', Radiology, vol. 210, no. 1, pp. 177-181.
Aassar OS, Fischbein NJ, Caputo GR, Kaplan MJ, Prince DC, Singer MI et al. Metastatic head and neck cancer: Role and usefulness of FDG PET in locating occult primary tumors. Radiology. 1999 Jan;210(1):177-181.
Aassar, O. Sami ; Fischbein, Nancy J. ; Caputo, Gary R ; Kaplan, Michael J. ; Prince, David C. ; Singer, Mark I. ; Dillon, William P. ; Hawkins, Randall A. / Metastatic head and neck cancer : Role and usefulness of FDG PET in locating occult primary tumors. In: Radiology. 1999 ; Vol. 210, No. 1. pp. 177-181.
@article{90249a8930fb4ed692c8cf986510c70b,
title = "Metastatic head and neck cancer: Role and usefulness of FDG PET in locating occult primary tumors",
abstract = "PURPOSE: To assess the usefulness of 2-[fluorine-18]fluoro-2-deoxy-D- glucose (FDG) positron emission tomography (PET) of the head and neck in locating occult primary lesions in patients with metastatic cervical adenopathy. MATERIALS AND METHODS: Seventeen patients with metastatic cervical adenopathy of unknown primary origin were referred for FDG PET of the head and neck. All patients had undergone correlative anatomic imaging within 1 month of FDG PET. Surgical, clinical, and histopathologic findings were used to assess the performance of FDG PET. RESULTS: Increased apical lung uptake at FDG PET led to a biopsy-proved diagnosis of primary lung cancer in two patients. Of the remaining 15 patients, 10 had a focus of increased activity; directed biopsy of these sites led to confirmation of a primary carcinoma in seven patients. Correlative anatomic imaging failed to demonstrate the primary sites of disease in two of these seven patients. None of the five patients with negative FDG PET studies have manifested evidence of a primary site of disease during follow-up of 8-42 months (mean, 29 months). CONCLUSION: FDG PET allows effective localization of the unknown primary site of origin in metastatic head and neck cancer and can contribute substantially to patient care.",
keywords = "Fluorine, Head and neck neoplasms, diagnosis, Head and neck neoplasms, emission CT (ECT), Head and neck neoplasms, secondary",
author = "Aassar, {O. Sami} and Fischbein, {Nancy J.} and Caputo, {Gary R} and Kaplan, {Michael J.} and Prince, {David C.} and Singer, {Mark I.} and Dillon, {William P.} and Hawkins, {Randall A.}",
year = "1999",
month = "1",
language = "English (US)",
volume = "210",
pages = "177--181",
journal = "Radiology",
issn = "0033-8419",
publisher = "Radiological Society of North America Inc.",
number = "1",

}

TY - JOUR

T1 - Metastatic head and neck cancer

T2 - Role and usefulness of FDG PET in locating occult primary tumors

AU - Aassar, O. Sami

AU - Fischbein, Nancy J.

AU - Caputo, Gary R

AU - Kaplan, Michael J.

AU - Prince, David C.

AU - Singer, Mark I.

AU - Dillon, William P.

AU - Hawkins, Randall A.

PY - 1999/1

Y1 - 1999/1

N2 - PURPOSE: To assess the usefulness of 2-[fluorine-18]fluoro-2-deoxy-D- glucose (FDG) positron emission tomography (PET) of the head and neck in locating occult primary lesions in patients with metastatic cervical adenopathy. MATERIALS AND METHODS: Seventeen patients with metastatic cervical adenopathy of unknown primary origin were referred for FDG PET of the head and neck. All patients had undergone correlative anatomic imaging within 1 month of FDG PET. Surgical, clinical, and histopathologic findings were used to assess the performance of FDG PET. RESULTS: Increased apical lung uptake at FDG PET led to a biopsy-proved diagnosis of primary lung cancer in two patients. Of the remaining 15 patients, 10 had a focus of increased activity; directed biopsy of these sites led to confirmation of a primary carcinoma in seven patients. Correlative anatomic imaging failed to demonstrate the primary sites of disease in two of these seven patients. None of the five patients with negative FDG PET studies have manifested evidence of a primary site of disease during follow-up of 8-42 months (mean, 29 months). CONCLUSION: FDG PET allows effective localization of the unknown primary site of origin in metastatic head and neck cancer and can contribute substantially to patient care.

AB - PURPOSE: To assess the usefulness of 2-[fluorine-18]fluoro-2-deoxy-D- glucose (FDG) positron emission tomography (PET) of the head and neck in locating occult primary lesions in patients with metastatic cervical adenopathy. MATERIALS AND METHODS: Seventeen patients with metastatic cervical adenopathy of unknown primary origin were referred for FDG PET of the head and neck. All patients had undergone correlative anatomic imaging within 1 month of FDG PET. Surgical, clinical, and histopathologic findings were used to assess the performance of FDG PET. RESULTS: Increased apical lung uptake at FDG PET led to a biopsy-proved diagnosis of primary lung cancer in two patients. Of the remaining 15 patients, 10 had a focus of increased activity; directed biopsy of these sites led to confirmation of a primary carcinoma in seven patients. Correlative anatomic imaging failed to demonstrate the primary sites of disease in two of these seven patients. None of the five patients with negative FDG PET studies have manifested evidence of a primary site of disease during follow-up of 8-42 months (mean, 29 months). CONCLUSION: FDG PET allows effective localization of the unknown primary site of origin in metastatic head and neck cancer and can contribute substantially to patient care.

KW - Fluorine

KW - Head and neck neoplasms, diagnosis

KW - Head and neck neoplasms, emission CT (ECT)

KW - Head and neck neoplasms, secondary

UR - http://www.scopus.com/inward/record.url?scp=0032899965&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032899965&partnerID=8YFLogxK

M3 - Article

C2 - 9885604

AN - SCOPUS:0032899965

VL - 210

SP - 177

EP - 181

JO - Radiology

JF - Radiology

SN - 0033-8419

IS - 1

ER -