Metaphyseal chondrodysplasia: Interesting findings on bone scintigraphy

A 9-year-old girl had a short stature and multiple bony deformities, including widening of the wrists, knee and ankle joints, and chest since the age of 1 month. Despite the administration of calcium and vitamin D, her deformities worsened. Laboratory investigations revealed normal blood biochemical parameters, including serum calcium, phosphorus, and alkaline phosphatase. Plain radiographs showed a fragmented appearance with marked widening and fraying of the metaphyses and of all long bones. The epiphyses of the long tubular bones of both the upper and lower extremities were bulbous. The radiologic results were consistent with metaphyseal chondrodysplasia, and radionuclide imaging reflected these findings.