Metal complexes as enzyme inhibitors

Angelique Y. Louie, Thomas J. Meade, S. J. Lippard

Research output: Contribution to journalArticle

258 Scopus citations

Abstract

Metal complexes are gaining wider applications as enzyme inhibitors for disease treatments. Factors such as specificity, bioavailability, compensatory effects and complex stability are taken into account before such complexes function as therapeutic agents. The applications of metal complex enzyme inhibitors to normal and abnormal physiology, infections and toxicity are discussed.

Original languageEnglish (US)
Pages (from-to)2711-2734
Number of pages24
JournalChemical Reviews
Volume99
Issue number9
DOIs
StatePublished - Sep 1999
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)

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    Louie, A. Y., Meade, T. J., & Lippard, S. J. (1999). Metal complexes as enzyme inhibitors. Chemical Reviews, 99(9), 2711-2734. https://doi.org/10.1021/cr9804285