Metal complexes as enzyme inhibitors

Angelique Y. Louie, Thomas J. Meade, S. J. Lippard

Research output: Contribution to journalArticle

251 Citations (Scopus)

Abstract

Metal complexes are gaining wider applications as enzyme inhibitors for disease treatments. Factors such as specificity, bioavailability, compensatory effects and complex stability are taken into account before such complexes function as therapeutic agents. The applications of metal complex enzyme inhibitors to normal and abnormal physiology, infections and toxicity are discussed.

Original languageEnglish (US)
Pages (from-to)2711-2734
Number of pages24
JournalChemical Reviews
Volume99
Issue number9
DOIs
StatePublished - Sep 1999
Externally publishedYes

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Coordination Complexes
Enzyme Inhibitors
Physiology
Toxicity
Biological Availability

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Louie, A. Y., Meade, T. J., & Lippard, S. J. (1999). Metal complexes as enzyme inhibitors. Chemical Reviews, 99(9), 2711-2734. https://doi.org/10.1021/cr9804285

Metal complexes as enzyme inhibitors. / Louie, Angelique Y.; Meade, Thomas J.; Lippard, S. J.

In: Chemical Reviews, Vol. 99, No. 9, 09.1999, p. 2711-2734.

Research output: Contribution to journalArticle

Louie, AY, Meade, TJ & Lippard, SJ 1999, 'Metal complexes as enzyme inhibitors', Chemical Reviews, vol. 99, no. 9, pp. 2711-2734. https://doi.org/10.1021/cr9804285
Louie AY, Meade TJ, Lippard SJ. Metal complexes as enzyme inhibitors. Chemical Reviews. 1999 Sep;99(9):2711-2734. https://doi.org/10.1021/cr9804285
Louie, Angelique Y. ; Meade, Thomas J. ; Lippard, S. J. / Metal complexes as enzyme inhibitors. In: Chemical Reviews. 1999 ; Vol. 99, No. 9. pp. 2711-2734.
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