Metabolomics insights into pathophysiological mechanisms of interstitial cystitis

Oliver Fiehn, Jayoung Kim

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Interstitial cystitis (IC), also known as painful bladder syndrome or bladder pain syndrome, is a chronic lower urinary tract syndrome characterized by pelvic pain, urinary urgency, and increased urinary frequency in the absence of bacterial infection or identifiable clinicopathology. IC can lead to long-term adverse effects on the patient's quality of life. Therefore, early diagnosis and better understanding of the mechanisms underlying IC are needed. Metabolomic studies of biofluids have become a powerful method for assessing disease mechanisms and biomarker discovery, which potentially address these important clinical needs. However, limited intensive metabolic profiles have been elucidated in IC. The article is a short review on metabolomic analyses that provide a unique fingerprint of IC with a focus on its use in determining a potential diagnostic biomarker associated with symptoms, a response predictor of therapy, and a prognostic marker.

Original languageEnglish (US)
Pages (from-to)106-114
Number of pages9
JournalInternational Neurourology Journal
Volume18
Issue number3
DOIs
StatePublished - 2014

Fingerprint

Interstitial Cystitis
Metabolomics
Biomarkers
Pelvic Pain
Metabolome
Dermatoglyphics
Urinary Tract
Bacterial Infections
Early Diagnosis
Urinary Bladder
Quality of Life
Pain

Keywords

  • Biological markers
  • Interstitial cystitis
  • Magnetic resonance spectroscopy
  • Mass spectrometry
  • Metabolomics

ASJC Scopus subject areas

  • Clinical Neurology
  • Urology
  • Neurology

Cite this

Metabolomics insights into pathophysiological mechanisms of interstitial cystitis. / Fiehn, Oliver; Kim, Jayoung.

In: International Neurourology Journal, Vol. 18, No. 3, 2014, p. 106-114.

Research output: Contribution to journalArticle

@article{aafc444e2cc64bd38a7a30e55c24dbbf,
title = "Metabolomics insights into pathophysiological mechanisms of interstitial cystitis",
abstract = "Interstitial cystitis (IC), also known as painful bladder syndrome or bladder pain syndrome, is a chronic lower urinary tract syndrome characterized by pelvic pain, urinary urgency, and increased urinary frequency in the absence of bacterial infection or identifiable clinicopathology. IC can lead to long-term adverse effects on the patient's quality of life. Therefore, early diagnosis and better understanding of the mechanisms underlying IC are needed. Metabolomic studies of biofluids have become a powerful method for assessing disease mechanisms and biomarker discovery, which potentially address these important clinical needs. However, limited intensive metabolic profiles have been elucidated in IC. The article is a short review on metabolomic analyses that provide a unique fingerprint of IC with a focus on its use in determining a potential diagnostic biomarker associated with symptoms, a response predictor of therapy, and a prognostic marker.",
keywords = "Biological markers, Interstitial cystitis, Magnetic resonance spectroscopy, Mass spectrometry, Metabolomics",
author = "Oliver Fiehn and Jayoung Kim",
year = "2014",
doi = "10.5213/inj.2014.18.3.106",
language = "English (US)",
volume = "18",
pages = "106--114",
journal = "International Neurourology Journal",
issn = "2093-4777",
publisher = "Korean Association of Medical Journal Edirors",
number = "3",

}

TY - JOUR

T1 - Metabolomics insights into pathophysiological mechanisms of interstitial cystitis

AU - Fiehn, Oliver

AU - Kim, Jayoung

PY - 2014

Y1 - 2014

N2 - Interstitial cystitis (IC), also known as painful bladder syndrome or bladder pain syndrome, is a chronic lower urinary tract syndrome characterized by pelvic pain, urinary urgency, and increased urinary frequency in the absence of bacterial infection or identifiable clinicopathology. IC can lead to long-term adverse effects on the patient's quality of life. Therefore, early diagnosis and better understanding of the mechanisms underlying IC are needed. Metabolomic studies of biofluids have become a powerful method for assessing disease mechanisms and biomarker discovery, which potentially address these important clinical needs. However, limited intensive metabolic profiles have been elucidated in IC. The article is a short review on metabolomic analyses that provide a unique fingerprint of IC with a focus on its use in determining a potential diagnostic biomarker associated with symptoms, a response predictor of therapy, and a prognostic marker.

AB - Interstitial cystitis (IC), also known as painful bladder syndrome or bladder pain syndrome, is a chronic lower urinary tract syndrome characterized by pelvic pain, urinary urgency, and increased urinary frequency in the absence of bacterial infection or identifiable clinicopathology. IC can lead to long-term adverse effects on the patient's quality of life. Therefore, early diagnosis and better understanding of the mechanisms underlying IC are needed. Metabolomic studies of biofluids have become a powerful method for assessing disease mechanisms and biomarker discovery, which potentially address these important clinical needs. However, limited intensive metabolic profiles have been elucidated in IC. The article is a short review on metabolomic analyses that provide a unique fingerprint of IC with a focus on its use in determining a potential diagnostic biomarker associated with symptoms, a response predictor of therapy, and a prognostic marker.

KW - Biological markers

KW - Interstitial cystitis

KW - Magnetic resonance spectroscopy

KW - Mass spectrometry

KW - Metabolomics

UR - http://www.scopus.com/inward/record.url?scp=84907404596&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84907404596&partnerID=8YFLogxK

U2 - 10.5213/inj.2014.18.3.106

DO - 10.5213/inj.2014.18.3.106

M3 - Article

AN - SCOPUS:84907404596

VL - 18

SP - 106

EP - 114

JO - International Neurourology Journal

JF - International Neurourology Journal

SN - 2093-4777

IS - 3

ER -