Metabolomics insights into pathophysiological mechanisms of interstitial cystitis

Oliver Fiehn, Jayoung Kim

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Interstitial cystitis (IC), also known as painful bladder syndrome or bladder pain syndrome, is a chronic lower urinary tract syndrome characterized by pelvic pain, urinary urgency, and increased urinary frequency in the absence of bacterial infection or identifiable clinicopathology. IC can lead to long-term adverse effects on the patient's quality of life. Therefore, early diagnosis and better understanding of the mechanisms underlying IC are needed. Metabolomic studies of biofluids have become a powerful method for assessing disease mechanisms and biomarker discovery, which potentially address these important clinical needs. However, limited intensive metabolic profiles have been elucidated in IC. The article is a short review on metabolomic analyses that provide a unique fingerprint of IC with a focus on its use in determining a potential diagnostic biomarker associated with symptoms, a response predictor of therapy, and a prognostic marker.

Original languageEnglish (US)
Pages (from-to)106-114
Number of pages9
JournalInternational Neurourology Journal
Volume18
Issue number3
DOIs
StatePublished - 2014

Keywords

  • Biological markers
  • Interstitial cystitis
  • Magnetic resonance spectroscopy
  • Mass spectrometry
  • Metabolomics

ASJC Scopus subject areas

  • Clinical Neurology
  • Urology
  • Neurology

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