Abstract
Interstitial cystitis (IC), also known as painful bladder syndrome or bladder pain syndrome, is a chronic lower urinary tract syndrome characterized by pelvic pain, urinary urgency, and increased urinary frequency in the absence of bacterial infection or identifiable clinicopathology. IC can lead to long-term adverse effects on the patient's quality of life. Therefore, early diagnosis and better understanding of the mechanisms underlying IC are needed. Metabolomic studies of biofluids have become a powerful method for assessing disease mechanisms and biomarker discovery, which potentially address these important clinical needs. However, limited intensive metabolic profiles have been elucidated in IC. The article is a short review on metabolomic analyses that provide a unique fingerprint of IC with a focus on its use in determining a potential diagnostic biomarker associated with symptoms, a response predictor of therapy, and a prognostic marker.
Original language | English (US) |
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Pages (from-to) | 106-114 |
Number of pages | 9 |
Journal | International Neurourology Journal |
Volume | 18 |
Issue number | 3 |
DOIs | |
State | Published - 2014 |
Keywords
- Biological markers
- Interstitial cystitis
- Magnetic resonance spectroscopy
- Mass spectrometry
- Metabolomics
ASJC Scopus subject areas
- Clinical Neurology
- Urology
- Neurology