Abstract
Interstitial cystitis (IC), also known as painful bladder syndrome or bladder pain syndrome, is a chronic lower urinary tract syndrome characterized by pelvic pain, urinary urgency, and increased urinary frequency in the absence of bacterial infection or identifiable clinicopathology. IC can lead to long-term adverse effects on the patient's quality of life. Therefore, early diagnosis and better understanding of the mechanisms underlying IC are needed. Metabolomic studies of biofluids have become a powerful method for assessing disease mechanisms and biomarker discovery, which potentially address these important clinical needs. However, limited intensive metabolic profiles have been elucidated in IC. The article is a short review on metabolomic analyses that provide a unique fingerprint of IC with a focus on its use in determining a potential diagnostic biomarker associated with symptoms, a response predictor of therapy, and a prognostic marker.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 106-114 |
| Number of pages | 9 |
| Journal | International Neurourology Journal |
| Volume | 18 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2014 |
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Keywords
- Biological markers
- Interstitial cystitis
- Magnetic resonance spectroscopy
- Mass spectrometry
- Metabolomics
ASJC Scopus subject areas
- Clinical Neurology
- Urology
- Neurology
Cite this
Metabolomics insights into pathophysiological mechanisms of interstitial cystitis. / Fiehn, Oliver; Kim, Jayoung.
In: International Neurourology Journal, Vol. 18, No. 3, 2014, p. 106-114.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Metabolomics insights into pathophysiological mechanisms of interstitial cystitis
AU - Fiehn, Oliver
AU - Kim, Jayoung
PY - 2014
Y1 - 2014
N2 - Interstitial cystitis (IC), also known as painful bladder syndrome or bladder pain syndrome, is a chronic lower urinary tract syndrome characterized by pelvic pain, urinary urgency, and increased urinary frequency in the absence of bacterial infection or identifiable clinicopathology. IC can lead to long-term adverse effects on the patient's quality of life. Therefore, early diagnosis and better understanding of the mechanisms underlying IC are needed. Metabolomic studies of biofluids have become a powerful method for assessing disease mechanisms and biomarker discovery, which potentially address these important clinical needs. However, limited intensive metabolic profiles have been elucidated in IC. The article is a short review on metabolomic analyses that provide a unique fingerprint of IC with a focus on its use in determining a potential diagnostic biomarker associated with symptoms, a response predictor of therapy, and a prognostic marker.
AB - Interstitial cystitis (IC), also known as painful bladder syndrome or bladder pain syndrome, is a chronic lower urinary tract syndrome characterized by pelvic pain, urinary urgency, and increased urinary frequency in the absence of bacterial infection or identifiable clinicopathology. IC can lead to long-term adverse effects on the patient's quality of life. Therefore, early diagnosis and better understanding of the mechanisms underlying IC are needed. Metabolomic studies of biofluids have become a powerful method for assessing disease mechanisms and biomarker discovery, which potentially address these important clinical needs. However, limited intensive metabolic profiles have been elucidated in IC. The article is a short review on metabolomic analyses that provide a unique fingerprint of IC with a focus on its use in determining a potential diagnostic biomarker associated with symptoms, a response predictor of therapy, and a prognostic marker.
KW - Biological markers
KW - Interstitial cystitis
KW - Magnetic resonance spectroscopy
KW - Mass spectrometry
KW - Metabolomics
UR - http://www.scopus.com/inward/record.url?scp=84907404596&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84907404596&partnerID=8YFLogxK
U2 - 10.5213/inj.2014.18.3.106
DO - 10.5213/inj.2014.18.3.106
M3 - Article
AN - SCOPUS:84907404596
VL - 18
SP - 106
EP - 114
JO - International Neurourology Journal
JF - International Neurourology Journal
SN - 2093-4777
IS - 3
ER -