Abstract
Metabolomics brings a different and complementary perspective to biomedical research and therapeutic development. Metabolites are measurable, directly responsible for health, and changeable through intervention. By definition, the concentrations of metabolites are the direct reflection of metabolism, and by measuring changes in metabolite concentrations, the full range of biochemical effects induced by a therapeutic intervention can be determined. In a clinical setting, metabolomics can be used to diagnose or predict disease, stratify patient populations by their specific metabolism, or to determine the safety or efficacy of a therapeutic intervention. Metabolomics is useful in virtually all aspects of biomedical research, and it is likely to evolve into an essential component of the drug discovery and development process.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 224-228 |
| Number of pages | 5 |
| Journal | Current Opinion in Molecular Therapeutics |
| Volume | 4 |
| Issue number | 3 |
| State | Published - Jun 2002 |
| Externally published | Yes |
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Keywords
- Drug development
- Metabolites
- Metabolomics
- Personalized medicine
- Profiling
ASJC Scopus subject areas
- Genetics
- Genetics(clinical)
- Pharmacology, Toxicology and Pharmaceutics(all)
Cite this
Metabolomics and biochemical profiling in drug discovery and development. / Watkins, Steven M.; German, J. Bruce.
In: Current Opinion in Molecular Therapeutics, Vol. 4, No. 3, 06.2002, p. 224-228.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Metabolomics and biochemical profiling in drug discovery and development
AU - Watkins, Steven M.
AU - German, J. Bruce
PY - 2002/6
Y1 - 2002/6
N2 - Metabolomics brings a different and complementary perspective to biomedical research and therapeutic development. Metabolites are measurable, directly responsible for health, and changeable through intervention. By definition, the concentrations of metabolites are the direct reflection of metabolism, and by measuring changes in metabolite concentrations, the full range of biochemical effects induced by a therapeutic intervention can be determined. In a clinical setting, metabolomics can be used to diagnose or predict disease, stratify patient populations by their specific metabolism, or to determine the safety or efficacy of a therapeutic intervention. Metabolomics is useful in virtually all aspects of biomedical research, and it is likely to evolve into an essential component of the drug discovery and development process.
AB - Metabolomics brings a different and complementary perspective to biomedical research and therapeutic development. Metabolites are measurable, directly responsible for health, and changeable through intervention. By definition, the concentrations of metabolites are the direct reflection of metabolism, and by measuring changes in metabolite concentrations, the full range of biochemical effects induced by a therapeutic intervention can be determined. In a clinical setting, metabolomics can be used to diagnose or predict disease, stratify patient populations by their specific metabolism, or to determine the safety or efficacy of a therapeutic intervention. Metabolomics is useful in virtually all aspects of biomedical research, and it is likely to evolve into an essential component of the drug discovery and development process.
KW - Drug development
KW - Metabolites
KW - Metabolomics
KW - Personalized medicine
KW - Profiling
UR - http://www.scopus.com/inward/record.url?scp=0036624293&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036624293&partnerID=8YFLogxK
M3 - Article
C2 - 12139307
AN - SCOPUS:0036624293
VL - 4
SP - 224
EP - 228
JO - Current Opinion in Molecular Therapeutics
JF - Current Opinion in Molecular Therapeutics
SN - 1464-8431
IS - 3
ER -