TY - JOUR
T1 - Metabolite Damage and Metabolite Damage Control in Plants
AU - Hanson, Andrew D.
AU - Henry, Christopher S.
AU - Fiehn, Oliver
AU - De Crécy-Lagard, Valérie
PY - 2016/4/29
Y1 - 2016/4/29
N2 - It is increasingly clear that (a) many metabolites undergo spontaneous or enzyme-catalyzed side reactions in vivo, (b) the damaged metabolites formed by these reactions can be harmful, and (c) organisms have biochemical systems that limit the buildup of damaged metabolites. These damage-control systems either return a damaged molecule to its pristine state (metabolite repair) or convert harmful molecules to harmless ones (damage preemption). Because all organisms share a core set of metabolites that suffer the same chemical and enzymatic damage reactions, certain damage-control systems are widely conserved across the kingdoms of life. Relatively few damage reactions and damage-control systems are well known. Uncovering new damage reactions and identifying the corresponding damaged metabolites, damage-control genes, and enzymes demands a coordinated mix of chemistry, metabolomics, cheminformatics, biochemistry, and comparative genomics. This review illustrates the above points using examples from plants, which are at least as prone to metabolite damage as other organisms.
AB - It is increasingly clear that (a) many metabolites undergo spontaneous or enzyme-catalyzed side reactions in vivo, (b) the damaged metabolites formed by these reactions can be harmful, and (c) organisms have biochemical systems that limit the buildup of damaged metabolites. These damage-control systems either return a damaged molecule to its pristine state (metabolite repair) or convert harmful molecules to harmless ones (damage preemption). Because all organisms share a core set of metabolites that suffer the same chemical and enzymatic damage reactions, certain damage-control systems are widely conserved across the kingdoms of life. Relatively few damage reactions and damage-control systems are well known. Uncovering new damage reactions and identifying the corresponding damaged metabolites, damage-control genes, and enzymes demands a coordinated mix of chemistry, metabolomics, cheminformatics, biochemistry, and comparative genomics. This review illustrates the above points using examples from plants, which are at least as prone to metabolite damage as other organisms.
KW - Cheminformatics
KW - Comparative genomics
KW - Damage preemption
KW - Damage repair
KW - Directed overflow
KW - Metabolomics
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U2 - 10.1146/annurev-arplant-043015-111648
DO - 10.1146/annurev-arplant-043015-111648
M3 - Review article
AN - SCOPUS:84968813917
VL - 67
SP - 131
EP - 152
JO - Annual Review of Plant Physiology and Plant Molecular Biology
JF - Annual Review of Plant Physiology and Plant Molecular Biology
SN - 1543-5008
ER -