TY - JOUR
T1 - Metabolism of lipoprotein remnants in humans
T2 - Studies during intestinal infusion of fat and cholesterol in subjects with varying expression of the low density lipoprotein receptor
AU - Eriksson, Mats
AU - Angelin, Bo
AU - Henriksson, Peter
AU - Ericsson, Sverker
AU - Vitols, Sigurd
AU - Berglund, Lars
PY - 1991
Y1 - 1991
N2 - To study the possible importance of the low density lipoprotein (LDL) receptor in regulating the degree of postprandial lipemia, a cholesterol-rich fat emulsion was infused into the duodenum of subjects who were divided into four groups based on the expected variation in the expression of the LDL receptor young men (n=11), elderly men (n=7), male patients on estrogen therapy (n=5), and patients with familial hypercholesterolemia (n=9). In familial hypercholesterolemia, fasting plasma levels of lipoproteins of d<1.006 g/ml, intermediate density lipoproteins, and LDLs were increased. During the fat infusion, the cholesterol and triglyceride contents in the d<1.006 g/ml fraction increased to a similar extent in all groups, whereas a concomitant reduction of LDL cholesterol levels was observed. The degree of the decrease in LDL cholesterol was positively correlated with the observed increase in triglycerides in the d<1.006 g/ml fraction. There were no signs of accumulation of intermediate density lipoproteins during infusion in any of the groups studied. The results indicate that the capacity for clearance of chylomicrons and chylomicron remnants is not affected by variation in LDL receptor expression.
AB - To study the possible importance of the low density lipoprotein (LDL) receptor in regulating the degree of postprandial lipemia, a cholesterol-rich fat emulsion was infused into the duodenum of subjects who were divided into four groups based on the expected variation in the expression of the LDL receptor young men (n=11), elderly men (n=7), male patients on estrogen therapy (n=5), and patients with familial hypercholesterolemia (n=9). In familial hypercholesterolemia, fasting plasma levels of lipoproteins of d<1.006 g/ml, intermediate density lipoproteins, and LDLs were increased. During the fat infusion, the cholesterol and triglyceride contents in the d<1.006 g/ml fraction increased to a similar extent in all groups, whereas a concomitant reduction of LDL cholesterol levels was observed. The degree of the decrease in LDL cholesterol was positively correlated with the observed increase in triglycerides in the d<1.006 g/ml fraction. There were no signs of accumulation of intermediate density lipoproteins during infusion in any of the groups studied. The results indicate that the capacity for clearance of chylomicrons and chylomicron remnants is not affected by variation in LDL receptor expression.
KW - Chylomicron remnants
KW - Chylomicrons
KW - Fat infusion
KW - Low density lipoprotein receptor
KW - Postprandial lipoproteins
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M3 - Article
C2 - 2065036
AN - SCOPUS:0025738198
VL - 11
SP - 827
EP - 837
JO - Arteriosclerosis, Thrombosis, and Vascular Biology
JF - Arteriosclerosis, Thrombosis, and Vascular Biology
SN - 1079-5642
IS - 4
ER -