Inflammation and hypercoagulability predispose to atherothrombosis and seem to be important features of the metabolic syndrome. The most convincing evidence is the association with increased levels of C-reactive protein. The hemostatic abnormality that has been most consistently associated with insulin resistance is an elevated plasminogen activator inhibitor-1 level. In contrast, markers of hypercoagulability have been associated inconsistently with hyperinsulinemia and glucose intolerance. Fibrinogen clusters with inflammatory factors, which suggests involvement of adipose tissue-generated inflammatory cytokines. Elevated von Willebrand's factor and factor VIII levels aggregate with indicators of endothelial injury, whereas vitamin K-dependent coagulation proteins correlate with triglyceride levels.
|Original language||English (US)|
|Number of pages||23|
|Journal||Endocrinology and Metabolism Clinics of North America|
|State||Published - Jun 2004|
ASJC Scopus subject areas