Metabolic syndrome: An appraisal of the pro-inflammatory and procoagulant status

Sridevi Devaraj, Robert S. Rosenson, Ishwarlal Jialal

Research output: Contribution to journalArticlepeer-review

110 Scopus citations


Inflammation and hypercoagulability predispose to atherothrombosis and seem to be important features of the metabolic syndrome. The most convincing evidence is the association with increased levels of C-reactive protein. The hemostatic abnormality that has been most consistently associated with insulin resistance is an elevated plasminogen activator inhibitor-1 level. In contrast, markers of hypercoagulability have been associated inconsistently with hyperinsulinemia and glucose intolerance. Fibrinogen clusters with inflammatory factors, which suggests involvement of adipose tissue-generated inflammatory cytokines. Elevated von Willebrand's factor and factor VIII levels aggregate with indicators of endothelial injury, whereas vitamin K-dependent coagulation proteins correlate with triglyceride levels.

Original languageEnglish (US)
Pages (from-to)431-453
Number of pages23
JournalEndocrinology and Metabolism Clinics of North America
Issue number2
StatePublished - Jun 2004

ASJC Scopus subject areas

  • Endocrinology
  • Biochemistry


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