Metabolic profiles and lipoprotein lipid concentrations in non-obese and obese patients with polycystic ovarian disease

S. Mahabeer, C. Naidoo, R. J. Norman, I. Jialal, K. Reddi, S. M. Joubert

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Clinical parameters, androgen status and lipoprotein lipid profiles were assessed in 10 non-obese and 10 obese patients with polycystic ovarian disease (PCOD) and reference subjects matched for age, height and weight. Both obese and non-obese women with PCOD had significantly higher androgen levels when compared to the reference groups. When comparison of lipoprotein lipid profiles were made between groups, non-obese women with PCOD had significantly higher total cholesterol, triglycerides and LDL-cholesterol levels than non-obese reference subjects. Obese PCOD women manifested significantly higher total cholesterol, LDL-cholesterol, cholesterol/HDL, and LDL/HDL values than did obese reference subjects. Correlations between serum androgens and lipoprotein lipid concentrations in PCOD and normal women were unhelpful. Both non-obese and obese patients with PCOD had significantly higher systolic and diastolic blood pressures (BPs) than the reference groups. Thus, both non-obese and obese women with PCOD manifest hyperandrogenaemia which may result in a male pattern of lipoprotein lipid concentrations.

Original languageEnglish (US)
Pages (from-to)537-540
Number of pages4
JournalHormone and Metabolic Research
Volume22
Issue number10
StatePublished - 1990
Externally publishedYes

Keywords

  • androgens
  • hyperandrogenism
  • hyperlipidaemia
  • lipids
  • obese and non-obese PCOD

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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    Mahabeer, S., Naidoo, C., Norman, R. J., Jialal, I., Reddi, K., & Joubert, S. M. (1990). Metabolic profiles and lipoprotein lipid concentrations in non-obese and obese patients with polycystic ovarian disease. Hormone and Metabolic Research, 22(10), 537-540.