Metabolic fluctuation during a muscle contraction cycle

Youngran Chung, Robert Sharman, Richard Carlsen, Steven W. Unger, Douglas Larson, Thomas Jue

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Gated 31P-nuclear magnetic resonance followed the metabolic fluctuation in rat gastrocnemius muscle during a contraction cycle. Within 16 ms after stimulation, the phosphocreatine (PCr) level drops 11.3% from its reference state. The PCr minimum corresponds closely to the time of maximum force contraction. P(i) increases stoichiometrically, while ATP remains constant. During a twitch, PCr hydrolysis produces 3.1 μmol ATP/g tissue, which is substantially higher than the reported 0.3 μmol ATP·twitch-·g tissue-1 derived from steady-state experiments. The results reveal that a substantial energy fluctuation accompanies a muscle twitch.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Cell Physiology
Volume274
Issue number3 43-3
StatePublished - Mar 1998

Keywords

  • Energetics
  • Metabolism
  • Nuclear magnetic resonance
  • Twitch

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology
  • Physiology
  • Physiology (medical)

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