Metabolic effects of high doses of manganese in rats

Carl L Keen, Deborah L. Baly, Bo Lönnerdal

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


The effects of acute manganese (Mn) toxicity on tissue manganese concentrations and on plasma glucose levels were investigated in adult male Sprague-Dawley rats. Manganese injection in all tissues analyzed was reflected by a significant increase in Mn concentration that was transitory. Changes in the molecular localization of Mn in liver following injection include both increases in protein-bound Mn and low molecular weight Mn complexes. A rapid, dose-responsive rise in blood glucose followed Mn injection, whereas circulating insulin levels decreased after injection. These data show that acute changes in tissue Mn levels can have a pronounced effect on carbohydrate metabolism.

Original languageEnglish (US)
Pages (from-to)309-315
Number of pages7
JournalBiological Trace Element Research
Issue number4
StatePublished - Aug 1984


  • from high doses
  • in rats
  • Manganese
  • manganese metabolism
  • manganese toxicity
  • metabolic effects of high doses
  • metabolism
  • of high dose Mn
  • toxicity

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry, medical
  • Inorganic Chemistry
  • Clinical Biochemistry
  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Endocrinology


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