Metabolic conditions and breast cancer risk among Los Angeles County Filipina Americans compared with Chinese and Japanese Americans

Anna H. Wu, Cheryl Vigen, Lesley M. Butler, Chiu Chen Tseng

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Accumulating evidence suggests that the aggregation of common metabolic conditions (high blood pressure, diabetes and dyslipidemia) is a risk factor for breast cancer. Breast cancer incidence has risen steadily in Asian American women, and whether these metabolic conditions contribute to breast cancer risk in certain Asian American subgroups is unknown. We investigated the role of physician-diagnosed hypertension, high cholesterol and diabetes separately, and in combination, in relation to the risk of breast cancer in a population-based case–control study of 2,167 Asian Americans diagnosed with breast cancer and 2,035 age and ethnicity matched control women in Los Angeles County. Compared to Asian American women who did not have any of the metabolic conditions, those with 1, 2 or 3 conditions showed a steady increase in risk (respective odds ratios were 1.12, 1.42 and 1.62; P trend = 0.001) with adjustment for covariates including body mass index. Similar significant trends were observed in Filipina Americans (P trend = 0.021), postmenopausal women (P trend =0.001), Asian women who were born in the United States (US) (P trend = 0.052) and migrants who have lived in the US for at least 20 years (P trend = 0.004), but not migrants who lived in the US for <20 years (P trend = 0.64). These results suggest that westernization in lifestyle (diet and physical inactivity) and corresponding increase in adiposity have contributed to the rising prevalence of these metabolic conditions, which in turn, are associated with an increase in breast cancer.

Original languageEnglish (US)
Pages (from-to)2450-2461
Number of pages12
JournalInternational Journal of Cancer
Volume141
Issue number12
DOIs
StatePublished - Dec 15 2017
Externally publishedYes

Fingerprint

Asian Americans
Los Angeles
Breast Neoplasms
Hypertension
Physician's Role
Adiposity
Dyslipidemias
Life Style
Body Mass Index
Odds Ratio
Cholesterol
Diet
Incidence
Population

Keywords

  • body size
  • Chinese
  • diabetes
  • Filipina
  • high cholesterol
  • hypertension
  • Japanese
  • metabolic factors

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Metabolic conditions and breast cancer risk among Los Angeles County Filipina Americans compared with Chinese and Japanese Americans. / Wu, Anna H.; Vigen, Cheryl; Butler, Lesley M.; Tseng, Chiu Chen.

In: International Journal of Cancer, Vol. 141, No. 12, 15.12.2017, p. 2450-2461.

Research output: Contribution to journalArticle

Wu, Anna H. ; Vigen, Cheryl ; Butler, Lesley M. ; Tseng, Chiu Chen. / Metabolic conditions and breast cancer risk among Los Angeles County Filipina Americans compared with Chinese and Japanese Americans. In: International Journal of Cancer. 2017 ; Vol. 141, No. 12. pp. 2450-2461.
@article{8b8ed996e2c14d339158b6234d8adf03,
title = "Metabolic conditions and breast cancer risk among Los Angeles County Filipina Americans compared with Chinese and Japanese Americans",
abstract = "Accumulating evidence suggests that the aggregation of common metabolic conditions (high blood pressure, diabetes and dyslipidemia) is a risk factor for breast cancer. Breast cancer incidence has risen steadily in Asian American women, and whether these metabolic conditions contribute to breast cancer risk in certain Asian American subgroups is unknown. We investigated the role of physician-diagnosed hypertension, high cholesterol and diabetes separately, and in combination, in relation to the risk of breast cancer in a population-based case–control study of 2,167 Asian Americans diagnosed with breast cancer and 2,035 age and ethnicity matched control women in Los Angeles County. Compared to Asian American women who did not have any of the metabolic conditions, those with 1, 2 or 3 conditions showed a steady increase in risk (respective odds ratios were 1.12, 1.42 and 1.62; P trend = 0.001) with adjustment for covariates including body mass index. Similar significant trends were observed in Filipina Americans (P trend = 0.021), postmenopausal women (P trend =0.001), Asian women who were born in the United States (US) (P trend = 0.052) and migrants who have lived in the US for at least 20 years (P trend = 0.004), but not migrants who lived in the US for <20 years (P trend = 0.64). These results suggest that westernization in lifestyle (diet and physical inactivity) and corresponding increase in adiposity have contributed to the rising prevalence of these metabolic conditions, which in turn, are associated with an increase in breast cancer.",
keywords = "body size, Chinese, diabetes, Filipina, high cholesterol, hypertension, Japanese, metabolic factors",
author = "Wu, {Anna H.} and Cheryl Vigen and Butler, {Lesley M.} and Tseng, {Chiu Chen}",
year = "2017",
month = "12",
day = "15",
doi = "10.1002/ijc.31018",
language = "English (US)",
volume = "141",
pages = "2450--2461",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "12",

}

TY - JOUR

T1 - Metabolic conditions and breast cancer risk among Los Angeles County Filipina Americans compared with Chinese and Japanese Americans

AU - Wu, Anna H.

AU - Vigen, Cheryl

AU - Butler, Lesley M.

AU - Tseng, Chiu Chen

PY - 2017/12/15

Y1 - 2017/12/15

N2 - Accumulating evidence suggests that the aggregation of common metabolic conditions (high blood pressure, diabetes and dyslipidemia) is a risk factor for breast cancer. Breast cancer incidence has risen steadily in Asian American women, and whether these metabolic conditions contribute to breast cancer risk in certain Asian American subgroups is unknown. We investigated the role of physician-diagnosed hypertension, high cholesterol and diabetes separately, and in combination, in relation to the risk of breast cancer in a population-based case–control study of 2,167 Asian Americans diagnosed with breast cancer and 2,035 age and ethnicity matched control women in Los Angeles County. Compared to Asian American women who did not have any of the metabolic conditions, those with 1, 2 or 3 conditions showed a steady increase in risk (respective odds ratios were 1.12, 1.42 and 1.62; P trend = 0.001) with adjustment for covariates including body mass index. Similar significant trends were observed in Filipina Americans (P trend = 0.021), postmenopausal women (P trend =0.001), Asian women who were born in the United States (US) (P trend = 0.052) and migrants who have lived in the US for at least 20 years (P trend = 0.004), but not migrants who lived in the US for <20 years (P trend = 0.64). These results suggest that westernization in lifestyle (diet and physical inactivity) and corresponding increase in adiposity have contributed to the rising prevalence of these metabolic conditions, which in turn, are associated with an increase in breast cancer.

AB - Accumulating evidence suggests that the aggregation of common metabolic conditions (high blood pressure, diabetes and dyslipidemia) is a risk factor for breast cancer. Breast cancer incidence has risen steadily in Asian American women, and whether these metabolic conditions contribute to breast cancer risk in certain Asian American subgroups is unknown. We investigated the role of physician-diagnosed hypertension, high cholesterol and diabetes separately, and in combination, in relation to the risk of breast cancer in a population-based case–control study of 2,167 Asian Americans diagnosed with breast cancer and 2,035 age and ethnicity matched control women in Los Angeles County. Compared to Asian American women who did not have any of the metabolic conditions, those with 1, 2 or 3 conditions showed a steady increase in risk (respective odds ratios were 1.12, 1.42 and 1.62; P trend = 0.001) with adjustment for covariates including body mass index. Similar significant trends were observed in Filipina Americans (P trend = 0.021), postmenopausal women (P trend =0.001), Asian women who were born in the United States (US) (P trend = 0.052) and migrants who have lived in the US for at least 20 years (P trend = 0.004), but not migrants who lived in the US for <20 years (P trend = 0.64). These results suggest that westernization in lifestyle (diet and physical inactivity) and corresponding increase in adiposity have contributed to the rising prevalence of these metabolic conditions, which in turn, are associated with an increase in breast cancer.

KW - body size

KW - Chinese

KW - diabetes

KW - Filipina

KW - high cholesterol

KW - hypertension

KW - Japanese

KW - metabolic factors

UR - http://www.scopus.com/inward/record.url?scp=85028939253&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85028939253&partnerID=8YFLogxK

U2 - 10.1002/ijc.31018

DO - 10.1002/ijc.31018

M3 - Article

C2 - 28842914

AN - SCOPUS:85028939253

VL - 141

SP - 2450

EP - 2461

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 12

ER -