Mesothelial Inclusions in Pelvic Lymph Nodes Initially Diagnosed as Metastatic Prostate Cancer; the Utility of Second Opinions and Genomic Testing in the Setting of Unexpected Results

Fadi Joudi, Bela S. Denes, Carolyn Mies, Alan W Shindel

Research output: Contribution to journalArticle

Abstract

Benign mesothelial inclusions in pelvic lymph nodes may be mistaken for metastatic disease in the setting of pelvic malignancy. In this case-report a patient with Low-Risk prostate cancer (confirmed by biopsy and genomic testing) underwent radical prostatectomy with pelvic lymph node dissection. The initial pathological diagnosis was organ-confined Gleason 3 + 3 = 6 cancer with metastasis to a pelvic lymph node. Upon review of the pathological specimen and immunohistochemical staining the lymph node tissue concerning for metastatic disease was recharacterized as mesothelial in origin. This case illustrates the importance of second opinions and immunohistochemistry for unexpected or unusual pathological findings.

Original languageEnglish (US)
Pages (from-to)A1
JournalUrology Case Reports
Volume10
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

Keywords

  • Genomics
  • Lymph nodes
  • Mesothelial inclusions
  • Metastasis
  • Prostate cancer
  • Risk-stratification

ASJC Scopus subject areas

  • Urology

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