Mesenchymal stem/stromal cell therapy for inflammatory bowel disease: An updated review with maintenance of remission

Maneesh Dave, Palashkumar Jaiswal, Fabio Cominelli

Research output: Contribution to journalReview articlepeer-review

Abstract

Purpose of review: There is a need for novel therapies for inflammatory bowel diseases (IBDs) that are well tolerated and effective. Currently, mesenchymal stem/stromal cells (MSCs) are being investigated in clinical trials for treatment of IBD. In this review, we update the recently published studies with an emphasis on the long-term efficacy of MSC therapy for IBD. Recent findings: A cumulative body of data, including a recent phase III randomized controlled trial demonstrated excellent fistula healing in patients with refractory Crohn's perianal fistulae treated via local injections of MSCs and with a good safety profile. Follow-up studies suggest long-term efficacy of MSC therapy for complex perianal Crohn's disease fistulae; however, the efficacy decreases over time and may necessitate repeat treatment. Systemic (intravenous) therapy for luminal IBD offers a relatively well tolerated alternative but its efficacy remains unclear. Summary: Recent studies demonstrate that MSCs are well tolerated and have an excellent short-term efficacy for the management of refractory fistulizing perianal Crohn's disease. The current data suggest that its influence may 'wear off' over time. More data on larger number of patients with longer duration of follow-up in the setting of a randomized placebo controlled trial are needed to confirm these promising results. For luminal IBD, there is a need for more mechanistic studies in representative preclinical murine models, and the results of an ongoing phase III randomized controlled trial are eagerly awaited.

Original languageEnglish (US)
Pages (from-to)59-68
Number of pages10
JournalCurrent opinion in gastroenterology
Volume33
Issue number1
DOIs
StatePublished - 2017
Externally publishedYes

Keywords

  • Crohn's disease
  • Mesenchymal stem/stromal cells
  • Perianal Crohn's fistulae
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology

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