Mesenchymal stem versus stromal cells: International Society for Cell & Gene Therapy (ISCT®) Mesenchymal Stromal Cell committee position statement on nomenclature

S. Viswanathan, Y. Shi, J. Galipeau, M. Krampera, K. Leblanc, I. Martin, J. Nolta, D. G. Phinney, L. Sensebe

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

The International Society for Cell & Gene Therapy (ISCT®) Mesenchymal Stromal Cell (ISCT MSC) committee offers a position statement to clarify the nomenclature of mesenchymal stromal cells (MSCs). The ISCT MSC committee continues to support the use of the acronym “MSCs” but recommends this be (i) supplemented by tissue-source origin of the cells, which would highlight tissue-specific properties; (ii) intended as MSCs unless rigorous evidence for stemness exists that can be supported by both in vitro and in vivo data; and (iii) associated with robust matrix of functional assays to demonstrate MSC properties, which are not generically defined but informed by the intended therapeutic mode of actions.

Original languageEnglish (US)
Pages (from-to)1019-1024
Number of pages6
JournalCytotherapy
Volume21
Issue number10
DOIs
StatePublished - Oct 2019

Keywords

  • differentiation
  • immunomodulation
  • mesenchymal stromal cells
  • nomenclature
  • paracrine secretion
  • self-renewal
  • stem cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology
  • Genetics(clinical)
  • Cell Biology
  • Cancer Research
  • Transplantation

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