TY - JOUR
T1 - Mesenchymal stem cell-based therapy for ischemic stroke
AU - Anderson, Johnathon D.
AU - Pham, Missy T.
AU - Contreras, Zelenia
AU - Hoon, Madeline
AU - Fink, Kyle D.
AU - Johansson, Henrik J.
AU - Rossignol, Julien
AU - Dunbar, Gary L.
AU - Showalter, Megan
AU - Fiehn, Oliver
AU - Bramlett, Charles S.
AU - Bardini, Renee L.
AU - Bauer, Gerhard
AU - Fury, Brian
AU - Hendrix, Kyle J.
AU - Chedin, Frederic
AU - El-Andaloussi, Samir
AU - Hwang, Billianna
AU - Mulligan, Michael S.
AU - Lehtiö, Janne
AU - Nolta, Jan A.
PY - 2016/11/1
Y1 - 2016/11/1
N2 - Ischemic stroke represents a major, worldwide health burden with increasing incidence. Patients affected by ischemic strokes currently have few clinically approved treatment options available. Most currently approved treatments for ischemic stroke have narrow therapeutic windows, severely limiting the number of patients able to be treated. Mesenchymal stem cells represent a promising novel treatment for ischemic stroke. Numerous studies have demonstrated that mesenchymal stem cells functionally improve outcomes in rodent models of ischemic stroke. Recent studies have also shown that exosomes secreted by mesenchymal stem cells mediate much of this effect. In the present review, we summarize the current literature on the use of mesenchymal stem cells to treat ischemic stroke. Further studies investigating the mechanisms underlying mesenchymal stem cells tissue healing effects are warranted and would be of benefit to the field.
AB - Ischemic stroke represents a major, worldwide health burden with increasing incidence. Patients affected by ischemic strokes currently have few clinically approved treatment options available. Most currently approved treatments for ischemic stroke have narrow therapeutic windows, severely limiting the number of patients able to be treated. Mesenchymal stem cells represent a promising novel treatment for ischemic stroke. Numerous studies have demonstrated that mesenchymal stem cells functionally improve outcomes in rodent models of ischemic stroke. Recent studies have also shown that exosomes secreted by mesenchymal stem cells mediate much of this effect. In the present review, we summarize the current literature on the use of mesenchymal stem cells to treat ischemic stroke. Further studies investigating the mechanisms underlying mesenchymal stem cells tissue healing effects are warranted and would be of benefit to the field.
KW - Exosomes
KW - Ischemic stroke
KW - Mesenchymal stem cells
UR - http://www.scopus.com/inward/record.url?scp=85025126675&partnerID=8YFLogxK
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U2 - 10.1186/s41016-016-0053-4
DO - 10.1186/s41016-016-0053-4
M3 - Review article
AN - SCOPUS:85025126675
VL - 2
JO - Chinese Neurosurgical Journal
JF - Chinese Neurosurgical Journal
SN - 2057-4967
IS - 1
M1 - 36
ER -