Mesenchymal neoplasms associated with type D retroviruses in macaques.

P. A. Marx, Linda J Lowenstine

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The type D subfamily of retroviruses contains five distinct viruses which are found in New and Old World monkeys. The retroviruses found in Old World macaque (genus Macaca) monkeys are exogenous to the species and upon injection induce a fatal simian acquired immune deficiency syndrome (SAIDS). Two serotypes of type D virus, SAIDS retrovirus types 1 and 2 (SRV-1 and SRV-2), are found in captive macaques in primate centres in the United States. In addition to SAIDS, two neoplasms, retroperitoneal fibromatosis (RF) and subcutaneous fibrosarcomas (SF), have been found in macaques with type D retrovirus-induced SAIDS. Only SRV-2 is found in association with RF, and only about 35% of SRV-2-infected macaques develop RF. SF is found in association with both serotypes, but less than 5% of infected monkeys develop SF. The RF in macaques is potentially a model for human disease since the lesions in macaques are similar to the idiopathic RF described in humans. Thus far, RF has not been found in species other than macaque or man. The complete sequence of three type D retroviruses is known. Importantly, no oncogenes are present in the viral genome. Therefore, the mechanisms for tumour induction which involve immunosuppressive or genetic properties of the virus that are distinct from classic oncogenes must be considered.

Original languageEnglish (US)
Pages (from-to)101-115
Number of pages15
JournalCancer Surveys
Volume6
Issue number1
StatePublished - 1987

Fingerprint

Betaretrovirus
Macaca
Fibroma
Simian Acquired Immunodeficiency Syndrome
Mason-Pfizer monkey virus
Fibrosarcoma
Neoplasms
Retroviridae
Viruses
Oncogenes
Haplorhini
Retroperitoneal Neoplasms
Platyrrhini
Cercopithecidae
Viral Genome
Immunosuppressive Agents
Primates

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Mesenchymal neoplasms associated with type D retroviruses in macaques. / Marx, P. A.; Lowenstine, Linda J.

In: Cancer Surveys, Vol. 6, No. 1, 1987, p. 101-115.

Research output: Contribution to journalArticle

@article{37fac823c8da4447b92dbc253b143ce3,
title = "Mesenchymal neoplasms associated with type D retroviruses in macaques.",
abstract = "The type D subfamily of retroviruses contains five distinct viruses which are found in New and Old World monkeys. The retroviruses found in Old World macaque (genus Macaca) monkeys are exogenous to the species and upon injection induce a fatal simian acquired immune deficiency syndrome (SAIDS). Two serotypes of type D virus, SAIDS retrovirus types 1 and 2 (SRV-1 and SRV-2), are found in captive macaques in primate centres in the United States. In addition to SAIDS, two neoplasms, retroperitoneal fibromatosis (RF) and subcutaneous fibrosarcomas (SF), have been found in macaques with type D retrovirus-induced SAIDS. Only SRV-2 is found in association with RF, and only about 35{\%} of SRV-2-infected macaques develop RF. SF is found in association with both serotypes, but less than 5{\%} of infected monkeys develop SF. The RF in macaques is potentially a model for human disease since the lesions in macaques are similar to the idiopathic RF described in humans. Thus far, RF has not been found in species other than macaque or man. The complete sequence of three type D retroviruses is known. Importantly, no oncogenes are present in the viral genome. Therefore, the mechanisms for tumour induction which involve immunosuppressive or genetic properties of the virus that are distinct from classic oncogenes must be considered.",
author = "Marx, {P. A.} and Lowenstine, {Linda J}",
year = "1987",
language = "English (US)",
volume = "6",
pages = "101--115",
journal = "Cancer Surveys",
issn = "0261-2429",
publisher = "Cold Spring Harbor Laboratory Press",
number = "1",

}

TY - JOUR

T1 - Mesenchymal neoplasms associated with type D retroviruses in macaques.

AU - Marx, P. A.

AU - Lowenstine, Linda J

PY - 1987

Y1 - 1987

N2 - The type D subfamily of retroviruses contains five distinct viruses which are found in New and Old World monkeys. The retroviruses found in Old World macaque (genus Macaca) monkeys are exogenous to the species and upon injection induce a fatal simian acquired immune deficiency syndrome (SAIDS). Two serotypes of type D virus, SAIDS retrovirus types 1 and 2 (SRV-1 and SRV-2), are found in captive macaques in primate centres in the United States. In addition to SAIDS, two neoplasms, retroperitoneal fibromatosis (RF) and subcutaneous fibrosarcomas (SF), have been found in macaques with type D retrovirus-induced SAIDS. Only SRV-2 is found in association with RF, and only about 35% of SRV-2-infected macaques develop RF. SF is found in association with both serotypes, but less than 5% of infected monkeys develop SF. The RF in macaques is potentially a model for human disease since the lesions in macaques are similar to the idiopathic RF described in humans. Thus far, RF has not been found in species other than macaque or man. The complete sequence of three type D retroviruses is known. Importantly, no oncogenes are present in the viral genome. Therefore, the mechanisms for tumour induction which involve immunosuppressive or genetic properties of the virus that are distinct from classic oncogenes must be considered.

AB - The type D subfamily of retroviruses contains five distinct viruses which are found in New and Old World monkeys. The retroviruses found in Old World macaque (genus Macaca) monkeys are exogenous to the species and upon injection induce a fatal simian acquired immune deficiency syndrome (SAIDS). Two serotypes of type D virus, SAIDS retrovirus types 1 and 2 (SRV-1 and SRV-2), are found in captive macaques in primate centres in the United States. In addition to SAIDS, two neoplasms, retroperitoneal fibromatosis (RF) and subcutaneous fibrosarcomas (SF), have been found in macaques with type D retrovirus-induced SAIDS. Only SRV-2 is found in association with RF, and only about 35% of SRV-2-infected macaques develop RF. SF is found in association with both serotypes, but less than 5% of infected monkeys develop SF. The RF in macaques is potentially a model for human disease since the lesions in macaques are similar to the idiopathic RF described in humans. Thus far, RF has not been found in species other than macaque or man. The complete sequence of three type D retroviruses is known. Importantly, no oncogenes are present in the viral genome. Therefore, the mechanisms for tumour induction which involve immunosuppressive or genetic properties of the virus that are distinct from classic oncogenes must be considered.

UR - http://www.scopus.com/inward/record.url?scp=0023472992&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023472992&partnerID=8YFLogxK

M3 - Article

VL - 6

SP - 101

EP - 115

JO - Cancer Surveys

JF - Cancer Surveys

SN - 0261-2429

IS - 1

ER -