Merkel cell carcinoma: current status of targeted and future potential for immunotherapies.

Bishr Aldabagh, Jayne S Joo, Siegrid S. Yu

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Merkel cell carcinoma is an aggressive neuroendocrine tumor with a high incidence of local recurrence, regional nodal and distant metastasis, and a high mortality rate. It has been linked to a polyomavirus in addition to immune suppression. Traditionally, treatment options have been limited to surgery and radiation therapy. Better understanding of the molecular pathways of infection and carcinogenesis has provided potential molecular targets and potential immunotherapies which are discussed in this review.

Original languageEnglish (US)
Pages (from-to)76-82
Number of pages7
JournalSeminars in Cutaneous Medicine and Surgery
Volume33
Issue number2
DOIs
StatePublished - 2014

ASJC Scopus subject areas

  • Dermatology
  • Surgery

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