Merkel cell carcinoma

current status of targeted and future potential for immunotherapies.

Bishr Aldabagh, Jayne S Joo, Siegrid S. Yu

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Merkel cell carcinoma is an aggressive neuroendocrine tumor with a high incidence of local recurrence, regional nodal and distant metastasis, and a high mortality rate. It has been linked to a polyomavirus in addition to immune suppression. Traditionally, treatment options have been limited to surgery and radiation therapy. Better understanding of the molecular pathways of infection and carcinogenesis has provided potential molecular targets and potential immunotherapies which are discussed in this review.

Original languageEnglish (US)
Pages (from-to)76-82
Number of pages7
JournalSeminars in Cutaneous Medicine and Surgery
Volume33
Issue number2
DOIs
StatePublished - 2014

Fingerprint

Merkel Cell Carcinoma
Polyomavirus
Neuroendocrine Tumors
Immunotherapy
Carcinogenesis
Radiotherapy
Neoplasm Metastasis
Recurrence
Mortality
Incidence
Infection
Therapeutics

ASJC Scopus subject areas

  • Dermatology
  • Surgery

Cite this

Merkel cell carcinoma : current status of targeted and future potential for immunotherapies. / Aldabagh, Bishr; Joo, Jayne S; Yu, Siegrid S.

In: Seminars in Cutaneous Medicine and Surgery, Vol. 33, No. 2, 2014, p. 76-82.

Research output: Contribution to journalReview article

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