Meperidine-halothane interaction in dogs

Eugene Steffey, R. Martucci, D. Howland, J. H. Asling, J. H. Eisele, C. HiRSCH

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


We studied the interaction of meperidine and halothane in 24 unmedicated, spontaneously breathing dogs. Intramuscular (i.m. ) injections of meperidine, 2.75 mg/kg, 5.5 mg/kg and 11.0 mg/kg reduced the minimal alveolar concentration (MAC) of halothane required for anaesthesia. The magnitude and duration of MAC depression were dose related. Plasma meperidine concentrations following an i.m. injection of 2.75 mg/kg were lower in the awake, unsedated dogs than in the dogs anaesthetized with halothane.

Original languageEnglish (US)
Pages (from-to)459-467
Number of pages9
JournalCanadian Anaesthetists' Society Journal
Issue number4
StatePublished - Jul 1 1977

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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