Memory CD4+ T lymphocytes in the gastrointestinal tract are a major source of cell-associated simian immunodeficiency virus in chronic nonpathogenic infection of african green monkeys

Joern E. Schmitz, Zhong Min M, Emily A. Hagan, Andrew B. Wilks, Kathryn L. Furr, Caitlyn H. Linde, Roland C. Zahn, Jason M. Brenchley, Chris J Miller, Sallie R. Permar

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Simian immunodeficiency virus (SIV) infection of natural hosts is characterized by nonpathogenic chronic viremia, maintenance of gastrointestinal epithelial barrier integrity, and low numbers of target cells. Assessment of cell-associated virus load in T cell subsets in multiple anatomic compartments of chronically SIV-infected sabeus African green monkeys (AGMs) revealed that gastrointestinal memory CD4+ T lymphocytes are a major source of cell-associated virus and a significant contributor to SIV viremia in AGMs.

Original languageEnglish (US)
Pages (from-to)11380-11385
Number of pages6
JournalJournal of Virology
Volume86
Issue number20
DOIs
StatePublished - Oct 2012

ASJC Scopus subject areas

  • Immunology
  • Virology

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