Memory B cells and CD8+ lymphocytes do not control seasonal influenza a virus replication after homologous Re-Challenge of rhesus macaques

Timothy D. Carroll, Shannon R. Matzinger, Linda Fritts, Michael B. McChesney, Chris J Miller

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

This study sought to define the role of memory lymphocytes in the protection from homologous influenza A virus re-challenge in rhesus macaques. Depleting monoclonal antibodies (mAb) were administered to the animals prior to their second experimental inoculation with a human seasonal influenza A virus strain. Treatment with either anti-CD8α or anti-CD20 mAbs prior to re-challenge had minimal effect on influenza A virus replication. Thus, in non-human primates with pre-existing anti-influenza A antibodies, memory B cells and CD8α+ T cells do not contribute to the control of virus replication after re-challenge with a homologous strain of influenza A virus.

Original languageEnglish (US)
Article numbere21756
JournalPLoS One
Volume6
Issue number6
DOIs
StatePublished - 2011

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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