TY - JOUR
T1 - Membranoproliferative Glomerulonephritis Associated with Nivolumab Therapy
AU - Cruz-Whitley, Jessica
AU - Giehl, Nolan
AU - Jen, Kuang Yu
AU - Young, Brian
N1 - Publisher Copyright:
© 2020 Jessica Cruz-Whitley et al.
PY - 2020
Y1 - 2020
N2 - Nivolumab is an immune checkpoint inhibitor that targets programmed death-1 on T cells and is designed to amplify an immunologic reaction against cancer cells. However, upregulation of the immune system with checkpoint inhibition is nonspecific, and it can be associated with certain renal side effects, the best documented of which is acute tubulointerstitial nephritis. We present a unique case of a patient with acute kidney injury associated with nephrotic syndrome shortly after starting nivolumab therapy for metastatic anal carcinoma. Subsequent renal biopsy revealed membranoproliferative glomerulonephritis (MPGN). We believe this represents the first reported direct case of nivolumab-associated MPGN. As immunotherapy becomes more widely used in cancer treatment, particular attention must be paid to possible consequences of immune checkpoint inhibitors.
AB - Nivolumab is an immune checkpoint inhibitor that targets programmed death-1 on T cells and is designed to amplify an immunologic reaction against cancer cells. However, upregulation of the immune system with checkpoint inhibition is nonspecific, and it can be associated with certain renal side effects, the best documented of which is acute tubulointerstitial nephritis. We present a unique case of a patient with acute kidney injury associated with nephrotic syndrome shortly after starting nivolumab therapy for metastatic anal carcinoma. Subsequent renal biopsy revealed membranoproliferative glomerulonephritis (MPGN). We believe this represents the first reported direct case of nivolumab-associated MPGN. As immunotherapy becomes more widely used in cancer treatment, particular attention must be paid to possible consequences of immune checkpoint inhibitors.
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U2 - 10.1155/2020/2638283
DO - 10.1155/2020/2638283
M3 - Article
AN - SCOPUS:85087623531
VL - 2020
JO - Case Reports in Nephrology
JF - Case Reports in Nephrology
SN - 2090-6641
M1 - 2638283
ER -