Membrane-type I matrix metalloproteinase and cell migration

Motoharu Seiki, Hidetoshi Mori, Masahiro Kajita, Takamasa Uekita, Yoshifumi Itoh

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Membrane-type 1 matrix metalloproteinase (MT1-MMP) is an integral membrane proteinase that performs processing of cell surface proteins and degradation of extracellular matrix (ECM) components. Through these proteolytic events, MT1-MMP regulates various cellular functions, including ECM turnover, promotion of cell migration and invasion, and morphogenic responses to extracellular stimuli. MT1-MMP has to be regulated strictly to accomplish its function appropriately at various steps, including at the transcriptional and post-translational levels. MT1-MMP was originally identified as an invasion-promoting enzyme expressed in malignant tumour cells, and also as a specific activator of proMMP-2, which is believed to play a role in invasion of the basement membrane. Since then, it has attracted attention as a membrane-associated MMP that promotes cancer cell invasion and angiogenesis by endothelial cells. Although MT1-MMP has now become one of the best characterized enzymes in the MMP family, there remain numerous unanswered questions. In this chapter, we summarize our recent findings on how MT1-MMP is regulated during cell migration, and how cell migration is regulated by MT1-MMP.

Original languageEnglish (US)
Pages (from-to)253-262
Number of pages10
JournalBiochemical Society Symposium
Issue number70
StatePublished - Dec 1 2003
Externally publishedYes

Fingerprint

Membrane-Associated Matrix Metalloproteinases
Matrix Metalloproteinase 14
Matrix Metalloproteinases
Cell Movement
Membranes
Extracellular Matrix
Cells
Endothelial cells
Enzymes
Basement Membrane
Proteolysis
Tumors
Neoplasms
Membrane Proteins
Peptide Hydrolases
Endothelial Cells
Degradation

ASJC Scopus subject areas

  • Biochemistry

Cite this

Seiki, M., Mori, H., Kajita, M., Uekita, T., & Itoh, Y. (2003). Membrane-type I matrix metalloproteinase and cell migration. Biochemical Society Symposium, (70), 253-262.

Membrane-type I matrix metalloproteinase and cell migration. / Seiki, Motoharu; Mori, Hidetoshi; Kajita, Masahiro; Uekita, Takamasa; Itoh, Yoshifumi.

In: Biochemical Society Symposium, No. 70, 01.12.2003, p. 253-262.

Research output: Contribution to journalArticle

Seiki, M, Mori, H, Kajita, M, Uekita, T & Itoh, Y 2003, 'Membrane-type I matrix metalloproteinase and cell migration', Biochemical Society Symposium, no. 70, pp. 253-262.
Seiki M, Mori H, Kajita M, Uekita T, Itoh Y. Membrane-type I matrix metalloproteinase and cell migration. Biochemical Society Symposium. 2003 Dec 1;(70):253-262.
Seiki, Motoharu ; Mori, Hidetoshi ; Kajita, Masahiro ; Uekita, Takamasa ; Itoh, Yoshifumi. / Membrane-type I matrix metalloproteinase and cell migration. In: Biochemical Society Symposium. 2003 ; No. 70. pp. 253-262.
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