Membrane reorganization during chilling: Implications for long-term stabilization of platelets

Fern Tablin, Willem F. Wolkers, Naomi J. Walker, Ann E. Oliver, Nelly M. Tsvetkova, Karine Gousset, Lois M. Crowe, John H. Crowe

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

This essay is a review of the various biophysical and biochemical events that make up the factors responsible for platelet cold-induced activation. It describes the formation of large membrane domains composed of raft aggregates that occur during chilling and storage. It also presents strong evidence that platelet membranes undergo lateral phase separation during prolonged storage in the cold and suggests that raft aggregation and lateral phase separation are key events which must be obviated to stabilize platelets and store them either in the frozen or in the dry state.

Original languageEnglish (US)
Pages (from-to)114-123
Number of pages10
JournalCryobiology
Volume43
Issue number2
DOIs
StatePublished - 2002

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

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    Tablin, F., Wolkers, W. F., Walker, N. J., Oliver, A. E., Tsvetkova, N. M., Gousset, K., Crowe, L. M., & Crowe, J. H. (2002). Membrane reorganization during chilling: Implications for long-term stabilization of platelets. Cryobiology, 43(2), 114-123. https://doi.org/10.1006/cryo.2001.2355