Membrane fatty acid composition shows Δ-6-desaturase abnormalities in Alzheimer's disease

T. Nakada, Ingrid Kwee, W. G. Ellis

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Brain membrane phospholipid fatty acid composition is investigated in Alzheimer's disease using fresh pathologically proven autopsy material. The most striking abnormalities in Alzheimer brains compared to age-matched controls are found in the n-6 line of polyunsaturated fatty acids (PUFA) showing an elevation of 18:2 (n - 6) associated with a reduction of 20:4 (n - 6) and 22:4 (n - 6). The findings strongly indicate abnormalities in Δ6-desaturation. The decrease in 22:6 (n-3) also supports Δ6-desaturase abnormalities. Alteration in PUFA desaturation/elongation processes and resultant membrane abnormalities may play a key role in the pathogenesis of Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)153-155
Number of pages3
JournalNeuroReport
Volume1
Issue number2
StatePublished - 1990

ASJC Scopus subject areas

  • Neuroscience(all)

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