Membrane bound IL-15 is increased on CD14 monocytes in early stages of MS

Adi Vaknin-Dembinsky, Steven Brass, Roopali Gandhi, Howard L. Weiner

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

IL-15 is a pro-inflammatory cytokine whose three-dimensional structure is similar to that of IL-2. IL-2 and IL-15 have similar as well as distinct biological functions. An active form of IL-15 that is membrane bound has also been described. Furthermore, IL-15 is known to play a role in autoimmune diseases. We thus investigated the expression of membrane bound IL-15 on monocytes (CD14+ cells) and studied its effect on T cell activation in MS patients. We found that unstimulated CD14+ cells from relapsing remitting MS patients had increased membrane bound IL-15. Those with high surface levels of IL-15 on monocytes were in the early stages of the disease. In addition, we found that T cells of MS patients had enhanced responsiveness to IL-15 and there was increased expression of IL-15 receptor on CD4+ T cells. Thus, IL-15 may be an important cytokine that drives Th1 responses early in the course of the disease and could serve as a target for immunotherapy and as an early marker in the immunologic staging of MS.

Original languageEnglish (US)
Pages (from-to)135-139
Number of pages5
JournalJournal of Neuroimmunology
Volume195
Issue number1-2
DOIs
StatePublished - Mar 2008
Externally publishedYes

Keywords

  • IL-15
  • Monocytes
  • Multiple sclerosis

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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