Abstract
A surface antigen on live, unfixed, bovine papilloma virus induced fibroma cells was demonstrated with the indirect immunofluorescence (IF) test. Sera from calves with experimentally produced fibromas contained antibody to cultured fibroma cells; this indicated exposure to the same antigen. No activity could be demonstrated with the same sera tested against cultured normal dermal fibroblasts. The serum antibody activity could be removed by absorption with tumor cells but not with normal cells. Cultured fibroma cells were negative for viral antigens by the direct IF test and electron microscopic examination. Sequential antibody titers indicated correlation with onset of tumor growth but not with progression or regression of fibromas.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 737-741 |
| Number of pages | 5 |
| Journal | Journal of the National Cancer Institute |
| Volume | 52 |
| Issue number | 3 |
| State | Published - 1974 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Membrane antigen of bovine papilloma virus induced fibroma cells. / Barthold, Stephen W; Olson, C.
In: Journal of the National Cancer Institute, Vol. 52, No. 3, 1974, p. 737-741.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Membrane antigen of bovine papilloma virus induced fibroma cells
AU - Barthold, Stephen W
AU - Olson, C.
PY - 1974
Y1 - 1974
N2 - A surface antigen on live, unfixed, bovine papilloma virus induced fibroma cells was demonstrated with the indirect immunofluorescence (IF) test. Sera from calves with experimentally produced fibromas contained antibody to cultured fibroma cells; this indicated exposure to the same antigen. No activity could be demonstrated with the same sera tested against cultured normal dermal fibroblasts. The serum antibody activity could be removed by absorption with tumor cells but not with normal cells. Cultured fibroma cells were negative for viral antigens by the direct IF test and electron microscopic examination. Sequential antibody titers indicated correlation with onset of tumor growth but not with progression or regression of fibromas.
AB - A surface antigen on live, unfixed, bovine papilloma virus induced fibroma cells was demonstrated with the indirect immunofluorescence (IF) test. Sera from calves with experimentally produced fibromas contained antibody to cultured fibroma cells; this indicated exposure to the same antigen. No activity could be demonstrated with the same sera tested against cultured normal dermal fibroblasts. The serum antibody activity could be removed by absorption with tumor cells but not with normal cells. Cultured fibroma cells were negative for viral antigens by the direct IF test and electron microscopic examination. Sequential antibody titers indicated correlation with onset of tumor growth but not with progression or regression of fibromas.
UR - http://www.scopus.com/inward/record.url?scp=0016372265&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016372265&partnerID=8YFLogxK
M3 - Article
C2 - 4363689
AN - SCOPUS:0016372265
VL - 52
SP - 737
EP - 741
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
SN - 0027-8874
IS - 3
ER -