Membrane antigen of bovine papilloma virus induced fibroma cells

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A surface antigen on live, unfixed, bovine papilloma virus induced fibroma cells was demonstrated with the indirect immunofluorescence (IF) test. Sera from calves with experimentally produced fibromas contained antibody to cultured fibroma cells; this indicated exposure to the same antigen. No activity could be demonstrated with the same sera tested against cultured normal dermal fibroblasts. The serum antibody activity could be removed by absorption with tumor cells but not with normal cells. Cultured fibroma cells were negative for viral antigens by the direct IF test and electron microscopic examination. Sequential antibody titers indicated correlation with onset of tumor growth but not with progression or regression of fibromas.

Original languageEnglish (US)
Pages (from-to)737-741
Number of pages5
JournalJournal of the National Cancer Institute
Volume52
Issue number3
StatePublished - 1974
Externally publishedYes

Fingerprint

Fibroma
Papilloma
Viruses
Antigens
Membranes
Antibodies
Cultured Cells
Serum
Direct Fluorescent Antibody Technique
Viral Antigens
Surface Antigens
Indirect Fluorescent Antibody Technique
Neoplasms
Fibroblasts
Electrons
Skin
Growth

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Membrane antigen of bovine papilloma virus induced fibroma cells. / Barthold, Stephen W; Olson, C.

In: Journal of the National Cancer Institute, Vol. 52, No. 3, 1974, p. 737-741.

Research output: Contribution to journalArticle

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