Membership in genetic groups predicts Alzheimer disease

Elizabeth H. Corder, Rong Huang, Heather M. Cathcart, Irene S. Lanham, Ginny R. Parker, Danny Cheng, Suzanne Smith, Shirley E. Poduslo

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

The multiple polymorphisms contributing to Alzheimer disease (AD) have been difficult to identify. Three essentially sufficient risk sets were found using a fuzzy latent classification statistical model; that is, grade-of-membership analysis, and genotypes for APOE, APOCI, LDLr, cystatin C, and cathepsin D (180 cases, 120 controls). These were: (a) CST3-GA and CTSD:CT; (b) APOE44 and LDLr8:GG and LDLr13:TJ; and (c) APOE34 and LDLr13:TC. Consonance with one of the groups and high aggregate membership carried >800-fold elevated risk for AD. The absence of these combinations defined low risk. APOE3/- with heterozygous promoter and receptor genotypes predicted long life without dementia.

Original languageEnglish (US)
Pages (from-to)89-93
Number of pages5
JournalRejuvenation Research
Volume9
Issue number1
DOIs
StatePublished - Mar 1 2006
Externally publishedYes

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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