Memantine for fragile x-associated tremor/ataxia syndrome: A randomized, double-blind, placebo-controlled trial

Andreea L Seritan, Danh V Nguyen, Yi Mu, Flora Tassone, James A. Bourgeois, Andrea Schneider, Jennifer B. Cogswell, Kylee R. Cook, Maureen A. Leehey, Jim Grigsby, John M. Olichney, Patrick E. Adams, Wendi Legg, Lin Zhang, Paul J. Hagerman, Randi J. Hagerman

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Objective: Memantine, an uncompetitive N-methyl-D-aspartate receptor antagonist, is currently approved by the US Food and Drug Administration for the treatment of moderate to severe Alzheimer's disease. Anecdotal reports have suggested that memantine may improve neurologic and cognitive symptoms of individuals with the neurodegenerative disease fragile X-associated tremor/ataxia syndrome (FXTAS); however, its efficacy and safety in this population have not been assessed in a controlled trial. Method: Individuals with FXTAS aged 34-80 years were enrolled in a randomized, double-blind, placebo-controlled, 1-year trial between September 2007 and August 2012. Inclusion required definite, probable, or possible FXTAS in clinical stages 1 -5 according to previously published criteria. Primary outcome measures were the Behavioral Dyscontrol Scale (BDS) score and CATSYS intention tremor severity. Results: Ninety-four participants were randomized from 205 screened; of those, 43 and 45 started treatment with memantine (titrated to 10 mg twice daily) and placebo, respectively.Thirty-four participants receiving memantine and 36 receiving placebo completed the 1-yearendpoint assessment (n = 70). Intention-to-treat analysis showed no improvement with respect to intention tremor severity (mean [SD] values with memantine vs placebo: 1.05 [0.73] vs 1.89 [2.19], P=.O47) or BDS score (16.12 [5.43] vs 15.72 [3.93], P=.727) at follow-up. Post hoc analyses of participants with early FXTAS (stage < 3), those with late FXTAS (stage > 3), and those in different age groups (<65 years and >65 years) also indicated no significant improvement. More frequent mild adverse events were observed in the placebo group, while more frequent moderate adverse events occurred in the memantine group (P=.OO7). Conclusion:This randomized, double-blind, placebo-controlled trial of memantine for individuals with FXTAS showed no benefit com pa red to placebo with respect to the selected outcome measures.

Original languageEnglish (US)
Pages (from-to)264-271
Number of pages8
JournalJournal of Clinical Psychiatry
Issue number3
StatePublished - 2014

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Arts and Humanities (miscellaneous)


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