Meiosis-specific RNA splicing in yeast

JoAnne Engebrecht, Karen Voelkel-Meiman, G. Shirleen Roeder

Research output: Contribution to journalArticle

148 Citations (Scopus)

Abstract

Previous studies have suggested that the differentiated state of meiosis in yeast is regulated primarily at the transcriptional level. This study reports a case of posttranscriptional regulation of a gene whose product is essential for meiosis. The MER2 gene is transcribed in mitosis as well as meiosis; however, the transcript is spliced efficiently to generate a functional gene product only in meiosis. Meiotic levels of splicing depend on the MER1 gene product, which is also essential for meiosis and which is produced only in meiotic cells. Therefore, at least one of the functions of the MER1 protein is to mediate splicing of the MER2 transcript. Genetic data suggest that the MER1 gene may also be responsible for splicing the transcript of at least one other gene.

Original languageEnglish (US)
Pages (from-to)1257-1268
Number of pages12
JournalCell
Volume66
Issue number6
DOIs
StatePublished - Sep 20 1991
Externally publishedYes

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RNA Splicing
Meiosis
Yeast
Genes
Yeasts
RNA
Mitosis
Proteins

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Engebrecht, J., Voelkel-Meiman, K., & Roeder, G. S. (1991). Meiosis-specific RNA splicing in yeast. Cell, 66(6), 1257-1268. https://doi.org/10.1016/0092-8674(91)90047-3

Meiosis-specific RNA splicing in yeast. / Engebrecht, JoAnne; Voelkel-Meiman, Karen; Roeder, G. Shirleen.

In: Cell, Vol. 66, No. 6, 20.09.1991, p. 1257-1268.

Research output: Contribution to journalArticle

Engebrecht, J, Voelkel-Meiman, K & Roeder, GS 1991, 'Meiosis-specific RNA splicing in yeast', Cell, vol. 66, no. 6, pp. 1257-1268. https://doi.org/10.1016/0092-8674(91)90047-3
Engebrecht J, Voelkel-Meiman K, Roeder GS. Meiosis-specific RNA splicing in yeast. Cell. 1991 Sep 20;66(6):1257-1268. https://doi.org/10.1016/0092-8674(91)90047-3
Engebrecht, JoAnne ; Voelkel-Meiman, Karen ; Roeder, G. Shirleen. / Meiosis-specific RNA splicing in yeast. In: Cell. 1991 ; Vol. 66, No. 6. pp. 1257-1268.
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