Megakaryocyte and platelet ultrastructure in the Wistar Furth rat

R. M. Leven, F. Tablin

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Wistar Furth (WF) rats were studied and compared with Sprague-Dawley (SD) rats to determine if ultrastructural abnormalities in platelets or megakaryocytes could explain their macrothrombocytopenia. WF rats had one third of the platelet count of healthy rats and two times the platelet volume. Megakaryocyte number was decreased and the size of mature stage three megakaryocytes also was decreased. WF platelets had large membranous inclusion, and otherwise showed normal ultrastructural morphology. The WF megakaryocytes showed abnormal aggregates of the demarcation membrane system. Ruthenium red staining was more intense on WF megakaryocytes and platelets, indicating a possible increase in surface mucopolysaccharides. It is possible that abnormal megakaryocyte membrane structure may lead to WF macrothrombocytopenia.

Original languageEnglish (US)
Pages (from-to)417-426
Number of pages10
JournalAmerican Journal of Pathology
Volume132
Issue number3
StatePublished - 1988

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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