Meeting Report: Spontaneous Lesions and Diseases in Wild, Captive-Bred, and Zoo-Housed Nonhuman Primates and in Nonhuman Primate Species Used in Drug Safety Studies

V. G. Sasseville, K. G. Mansfield, J. L. Mankowski, C. Tremblay, K. A. Terio, K. Mätz-Rensing, E. Gruber-Dujardin, M. A. Delaney, L. D. Schmidt, D. Liu, J. E. Markovits, M. Owston, C. Harbison, S. Shanmukhappa, A. D. Miller, S. Kaliyaperumal, B. T. Assaf, L. Kattenhorn, S. Cummings Macri, H. A. SimmonsA. Baldessari, P. Sharma, C. Courtney, A. Bradley, J. M. Cline, J. F. Reindel, D. L. Hutto, R. J. Montali, Linda J Lowenstine

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The combination of loss of habitat, human population encroachment, and increased demand of select nonhuman primates for biomedical research has significantly affected populations. There remains a need for knowledge and expertise in understanding background findings as related to the age, source, strain, and disease status of nonhuman primates. In particular, for safety/biomedical studies, a broader understanding and documentation of lesions would help clarify background from drug-related findings. A workshop and a minisymposium on spontaneous lesions and diseases in nonhuman primates were sponsored by the concurrent Annual Meetings of the American College of Veterinary Pathologists and the American Society for Veterinary Clinical Pathology held December 3-4, 2011, in Nashville, Tennessee. The first session had presentations from Drs Lowenstine and Montali, pathologists with extensive experience in wild and zoo populations of nonhuman primates, which was followed by presentations of 20 unique case reports of rare or newly observed spontaneous lesions in nonhuman primates (see online files for access to digital whole-slide images corresponding to each case report at http://www.scanscope.com/ACVP%20Slide%20Seminars/2011/Primate%20Pathology/view.apml). The minisymposium was composed of 5 nonhuman-primate researchers (Drs Bradley, Cline, Sasseville, Miller, Hutto) who concentrated on background and spontaneous lesions in nonhuman primates used in drug safety studies. Cynomolgus and rhesus macaques were emphasized, with some material presented on common marmosets. Congenital, acquired, inflammatory, and neoplastic changes were highlighed with a focus on clinical, macroscopic, and histopathologic findings that could confound the interpretation of drug safety studies.

Original languageEnglish (US)
Pages (from-to)1057-1069
Number of pages13
JournalVeterinary Pathology
Volume49
Issue number6
DOIs
StatePublished - 2012

Fingerprint

zoos
lesions (animal)
Primates
breeds
Safety
drugs
Pharmaceutical Preparations
Veterinary Pathology
Population
case studies
Callithrix
Callithrix jacchus
Clinical Pathology
Macaca fascicularis
biomedical research
Macaca mulatta
habitat destruction
human population
Documentation
Ecosystem

Keywords

  • amyloidosis
  • Aotus trivirgatus
  • Armillifer agkistrodontis
  • Aspergillus fumigatus
  • bonobo
  • Brunner's gland hyperplasia
  • Callithrix jacchus
  • cardiomyopathy
  • Cebussp
  • Cercocebus torquatus torquatus
  • Cercopithecus nictitans
  • chimpanzee
  • Chlorocebus aethiops
  • Chromobacterium violaceum
  • colitis
  • Cryptosporidium muris-like
  • cytomegalovirus
  • diabetic nephropathy
  • encephalitis
  • enteritis
  • ependymoblastoma
  • epitheliotropic lymphoma
  • gorilla
  • Gorilla beringei beringei
  • Helicobacter heilmannii-like
  • hyperadrenocorticism
  • intestinal carcinoma
  • lymphocytic choriomeningitis virus
  • Macaca fascicularis
  • Macaca mulatta
  • Macaca nemestrina
  • macaque
  • Mandrillus sphinx
  • marmoset
  • metapneumovirus
  • multiple myeloma
  • oncocytic adrenocortical carcinoma
  • orangutan
  • ovarian teratoma
  • Pan paniscus
  • Pan troglodytes
  • papillomavirus
  • Papio cynocephalus
  • pheochromocytoma
  • Plasmodium inui
  • pneumonia
  • Pongo pygmaeus
  • Saguinus oedipus
  • simian human immunodeficiency virus
  • simian immunodeficiency virus
  • squamous cell carcinoma
  • tamarin

ASJC Scopus subject areas

  • veterinary(all)
  • Medicine(all)

Cite this

Meeting Report : Spontaneous Lesions and Diseases in Wild, Captive-Bred, and Zoo-Housed Nonhuman Primates and in Nonhuman Primate Species Used in Drug Safety Studies. / Sasseville, V. G.; Mansfield, K. G.; Mankowski, J. L.; Tremblay, C.; Terio, K. A.; Mätz-Rensing, K.; Gruber-Dujardin, E.; Delaney, M. A.; Schmidt, L. D.; Liu, D.; Markovits, J. E.; Owston, M.; Harbison, C.; Shanmukhappa, S.; Miller, A. D.; Kaliyaperumal, S.; Assaf, B. T.; Kattenhorn, L.; Macri, S. Cummings; Simmons, H. A.; Baldessari, A.; Sharma, P.; Courtney, C.; Bradley, A.; Cline, J. M.; Reindel, J. F.; Hutto, D. L.; Montali, R. J.; Lowenstine, Linda J.

In: Veterinary Pathology, Vol. 49, No. 6, 2012, p. 1057-1069.

Research output: Contribution to journalArticle

Sasseville, VG, Mansfield, KG, Mankowski, JL, Tremblay, C, Terio, KA, Mätz-Rensing, K, Gruber-Dujardin, E, Delaney, MA, Schmidt, LD, Liu, D, Markovits, JE, Owston, M, Harbison, C, Shanmukhappa, S, Miller, AD, Kaliyaperumal, S, Assaf, BT, Kattenhorn, L, Macri, SC, Simmons, HA, Baldessari, A, Sharma, P, Courtney, C, Bradley, A, Cline, JM, Reindel, JF, Hutto, DL, Montali, RJ & Lowenstine, LJ 2012, 'Meeting Report: Spontaneous Lesions and Diseases in Wild, Captive-Bred, and Zoo-Housed Nonhuman Primates and in Nonhuman Primate Species Used in Drug Safety Studies', Veterinary Pathology, vol. 49, no. 6, pp. 1057-1069. https://doi.org/10.1177/0300985812461655
Sasseville, V. G. ; Mansfield, K. G. ; Mankowski, J. L. ; Tremblay, C. ; Terio, K. A. ; Mätz-Rensing, K. ; Gruber-Dujardin, E. ; Delaney, M. A. ; Schmidt, L. D. ; Liu, D. ; Markovits, J. E. ; Owston, M. ; Harbison, C. ; Shanmukhappa, S. ; Miller, A. D. ; Kaliyaperumal, S. ; Assaf, B. T. ; Kattenhorn, L. ; Macri, S. Cummings ; Simmons, H. A. ; Baldessari, A. ; Sharma, P. ; Courtney, C. ; Bradley, A. ; Cline, J. M. ; Reindel, J. F. ; Hutto, D. L. ; Montali, R. J. ; Lowenstine, Linda J. / Meeting Report : Spontaneous Lesions and Diseases in Wild, Captive-Bred, and Zoo-Housed Nonhuman Primates and in Nonhuman Primate Species Used in Drug Safety Studies. In: Veterinary Pathology. 2012 ; Vol. 49, No. 6. pp. 1057-1069.
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AU - Sasseville, V. G.

AU - Mansfield, K. G.

AU - Mankowski, J. L.

AU - Tremblay, C.

AU - Terio, K. A.

AU - Mätz-Rensing, K.

AU - Gruber-Dujardin, E.

AU - Delaney, M. A.

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AU - Harbison, C.

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AU - Baldessari, A.

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AU - Montali, R. J.

AU - Lowenstine, Linda J

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N2 - The combination of loss of habitat, human population encroachment, and increased demand of select nonhuman primates for biomedical research has significantly affected populations. There remains a need for knowledge and expertise in understanding background findings as related to the age, source, strain, and disease status of nonhuman primates. In particular, for safety/biomedical studies, a broader understanding and documentation of lesions would help clarify background from drug-related findings. A workshop and a minisymposium on spontaneous lesions and diseases in nonhuman primates were sponsored by the concurrent Annual Meetings of the American College of Veterinary Pathologists and the American Society for Veterinary Clinical Pathology held December 3-4, 2011, in Nashville, Tennessee. The first session had presentations from Drs Lowenstine and Montali, pathologists with extensive experience in wild and zoo populations of nonhuman primates, which was followed by presentations of 20 unique case reports of rare or newly observed spontaneous lesions in nonhuman primates (see online files for access to digital whole-slide images corresponding to each case report at http://www.scanscope.com/ACVP%20Slide%20Seminars/2011/Primate%20Pathology/view.apml). The minisymposium was composed of 5 nonhuman-primate researchers (Drs Bradley, Cline, Sasseville, Miller, Hutto) who concentrated on background and spontaneous lesions in nonhuman primates used in drug safety studies. Cynomolgus and rhesus macaques were emphasized, with some material presented on common marmosets. Congenital, acquired, inflammatory, and neoplastic changes were highlighed with a focus on clinical, macroscopic, and histopathologic findings that could confound the interpretation of drug safety studies.

AB - The combination of loss of habitat, human population encroachment, and increased demand of select nonhuman primates for biomedical research has significantly affected populations. There remains a need for knowledge and expertise in understanding background findings as related to the age, source, strain, and disease status of nonhuman primates. In particular, for safety/biomedical studies, a broader understanding and documentation of lesions would help clarify background from drug-related findings. A workshop and a minisymposium on spontaneous lesions and diseases in nonhuman primates were sponsored by the concurrent Annual Meetings of the American College of Veterinary Pathologists and the American Society for Veterinary Clinical Pathology held December 3-4, 2011, in Nashville, Tennessee. The first session had presentations from Drs Lowenstine and Montali, pathologists with extensive experience in wild and zoo populations of nonhuman primates, which was followed by presentations of 20 unique case reports of rare or newly observed spontaneous lesions in nonhuman primates (see online files for access to digital whole-slide images corresponding to each case report at http://www.scanscope.com/ACVP%20Slide%20Seminars/2011/Primate%20Pathology/view.apml). The minisymposium was composed of 5 nonhuman-primate researchers (Drs Bradley, Cline, Sasseville, Miller, Hutto) who concentrated on background and spontaneous lesions in nonhuman primates used in drug safety studies. Cynomolgus and rhesus macaques were emphasized, with some material presented on common marmosets. Congenital, acquired, inflammatory, and neoplastic changes were highlighed with a focus on clinical, macroscopic, and histopathologic findings that could confound the interpretation of drug safety studies.

KW - amyloidosis

KW - Aotus trivirgatus

KW - Armillifer agkistrodontis

KW - Aspergillus fumigatus

KW - bonobo

KW - Brunner's gland hyperplasia

KW - Callithrix jacchus

KW - cardiomyopathy

KW - Cebussp

KW - Cercocebus torquatus torquatus

KW - Cercopithecus nictitans

KW - chimpanzee

KW - Chlorocebus aethiops

KW - Chromobacterium violaceum

KW - colitis

KW - Cryptosporidium muris-like

KW - cytomegalovirus

KW - diabetic nephropathy

KW - encephalitis

KW - enteritis

KW - ependymoblastoma

KW - epitheliotropic lymphoma

KW - gorilla

KW - Gorilla beringei beringei

KW - Helicobacter heilmannii-like

KW - hyperadrenocorticism

KW - intestinal carcinoma

KW - lymphocytic choriomeningitis virus

KW - Macaca fascicularis

KW - Macaca mulatta

KW - Macaca nemestrina

KW - macaque

KW - Mandrillus sphinx

KW - marmoset

KW - metapneumovirus

KW - multiple myeloma

KW - oncocytic adrenocortical carcinoma

KW - orangutan

KW - ovarian teratoma

KW - Pan paniscus

KW - Pan troglodytes

KW - papillomavirus

KW - Papio cynocephalus

KW - pheochromocytoma

KW - Plasmodium inui

KW - pneumonia

KW - Pongo pygmaeus

KW - Saguinus oedipus

KW - simian human immunodeficiency virus

KW - simian immunodeficiency virus

KW - squamous cell carcinoma

KW - tamarin

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