Meeting report: High-throughput technologies for in vivo imaging agents

Robert J. Gillies, John M. Hoffman, Kit Lam, Anne E. Menkens, David R. Piwnica-Worms, Daniel C. Sullivan, Ralph Weissleder

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Combinatorial chemistry and high-throughput screening have become standard tools for discovering new drug candidates with suitable pharmacological properties. Now, those same technologies are starting to be applied to the problem of discovering novel in vivo imaging agents. Important differences in the biological and pharmacological properties needed for imaging agents, compared to those for a therapeutic agent, require new screening methods that emphasize those characteristics, such as optimized residence time and tissue specificity, that make for a good imaging agent candidate.

Original languageEnglish (US)
Pages (from-to)98-103
Number of pages6
JournalMolecular Imaging
Volume4
Issue number2
StatePublished - Apr 2005

Keywords

  • Combinatorial chemistry
  • High-throughput assays
  • Imaging agent libraries
  • Informatics
  • Screening models

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Gillies, R. J., Hoffman, J. M., Lam, K., Menkens, A. E., Piwnica-Worms, D. R., Sullivan, D. C., & Weissleder, R. (2005). Meeting report: High-throughput technologies for in vivo imaging agents. Molecular Imaging, 4(2), 98-103.