Meeting report: Hazard assessment for nanoparticles-report from an interdisciplinary workshop

John M. Balbus, Andrew D. Maynard, Vicki L. Colvin, Vincent Castranova, George P. Daston, Richard A. Denison, Kevin L. Dreher, Peter L. Goering, Alan M. Goldberg, Kristen M. Kulinowski, Nancy A. Monteiro-Riviere, Günter Oberdörster, Gilbert S. Omenn, Kent E Pinkerton, Kenneth S. Ramos, Kathleen M. Rest, Jennifer B. Sass, Ellen K. Silbergeld, Brian A. Wong

Research output: Contribution to journalArticle

193 Citations (Scopus)

Abstract

In this report we present the findings from a nanotoxicology workshop held 6-7 April 2006 at the Woodrow Wilson International Center for Scholars in Washington, DC. Over 2 days, 26 scientists from government, academia, industry, and nonprofit organizations addressed two specific questions: what information is needed to understand the human health impact of engineered nanoparticles and how is this information best obtained? To assess hazards of nanoparticles in the near-term, most participants noted the need to use existing in vivo toxicologic tests because of their greater familiarity and interpretability. For all types of toxicology tests, the best measures of nanoparticle dose need to be determined. Most participants agreed that a standard set of nanoparticles should be validated by laboratories worldwide and made available for benchmarking tests of other newly created nanoparticles. The group concluded that a battery of tests should be developed to uncover particularly hazardous properties. Given the large number of diverse materials, most participants favored a tiered approach. Over the long term, research aimed at developing a mechanistic understanding of the numerous characteristics that influence nanoparticle toxicity was deemed essential. Predicting the potential toxicity of emerging nanoparticles will require hypothesis-driven research that elucidates how physicochemical parameters influence toxic effects on biological systems. Research needs should be determined in the context of the current availability of testing methods for nanoscale particles. Finally, the group identified general policy and strategic opportunities to accelerate the development and implementation of testing protocols and ensure that the information generated is translated effectively for all stakeholders.

Original languageEnglish (US)
Pages (from-to)1654-1659
Number of pages6
JournalEnvironmental Health Perspectives
Volume115
Issue number11
DOIs
StatePublished - Nov 2007

Fingerprint

hazard assessment
Nanoparticles
Hazards
Education
Toxicity
Research
Nonprofit Organizations
toxicity
Benchmarking
nonprofit organization
familiarity
benchmarking
testing method
Poisons
health impact
Testing
toxicology
Biological systems
nanoparticle
Toxicology

Keywords

  • Nanomaterials
  • Nanoparticle
  • Nanotechnology
  • Nanotoxicology
  • Particle toxicology

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health
  • Environmental Science(all)
  • Environmental Chemistry

Cite this

Balbus, J. M., Maynard, A. D., Colvin, V. L., Castranova, V., Daston, G. P., Denison, R. A., ... Wong, B. A. (2007). Meeting report: Hazard assessment for nanoparticles-report from an interdisciplinary workshop. Environmental Health Perspectives, 115(11), 1654-1659. https://doi.org/10.1289/ehp.10327

Meeting report : Hazard assessment for nanoparticles-report from an interdisciplinary workshop. / Balbus, John M.; Maynard, Andrew D.; Colvin, Vicki L.; Castranova, Vincent; Daston, George P.; Denison, Richard A.; Dreher, Kevin L.; Goering, Peter L.; Goldberg, Alan M.; Kulinowski, Kristen M.; Monteiro-Riviere, Nancy A.; Oberdörster, Günter; Omenn, Gilbert S.; Pinkerton, Kent E; Ramos, Kenneth S.; Rest, Kathleen M.; Sass, Jennifer B.; Silbergeld, Ellen K.; Wong, Brian A.

In: Environmental Health Perspectives, Vol. 115, No. 11, 11.2007, p. 1654-1659.

Research output: Contribution to journalArticle

Balbus, JM, Maynard, AD, Colvin, VL, Castranova, V, Daston, GP, Denison, RA, Dreher, KL, Goering, PL, Goldberg, AM, Kulinowski, KM, Monteiro-Riviere, NA, Oberdörster, G, Omenn, GS, Pinkerton, KE, Ramos, KS, Rest, KM, Sass, JB, Silbergeld, EK & Wong, BA 2007, 'Meeting report: Hazard assessment for nanoparticles-report from an interdisciplinary workshop', Environmental Health Perspectives, vol. 115, no. 11, pp. 1654-1659. https://doi.org/10.1289/ehp.10327
Balbus JM, Maynard AD, Colvin VL, Castranova V, Daston GP, Denison RA et al. Meeting report: Hazard assessment for nanoparticles-report from an interdisciplinary workshop. Environmental Health Perspectives. 2007 Nov;115(11):1654-1659. https://doi.org/10.1289/ehp.10327
Balbus, John M. ; Maynard, Andrew D. ; Colvin, Vicki L. ; Castranova, Vincent ; Daston, George P. ; Denison, Richard A. ; Dreher, Kevin L. ; Goering, Peter L. ; Goldberg, Alan M. ; Kulinowski, Kristen M. ; Monteiro-Riviere, Nancy A. ; Oberdörster, Günter ; Omenn, Gilbert S. ; Pinkerton, Kent E ; Ramos, Kenneth S. ; Rest, Kathleen M. ; Sass, Jennifer B. ; Silbergeld, Ellen K. ; Wong, Brian A. / Meeting report : Hazard assessment for nanoparticles-report from an interdisciplinary workshop. In: Environmental Health Perspectives. 2007 ; Vol. 115, No. 11. pp. 1654-1659.
@article{1a6e4f3ca24c41968facf850cf527a57,
title = "Meeting report: Hazard assessment for nanoparticles-report from an interdisciplinary workshop",
abstract = "In this report we present the findings from a nanotoxicology workshop held 6-7 April 2006 at the Woodrow Wilson International Center for Scholars in Washington, DC. Over 2 days, 26 scientists from government, academia, industry, and nonprofit organizations addressed two specific questions: what information is needed to understand the human health impact of engineered nanoparticles and how is this information best obtained? To assess hazards of nanoparticles in the near-term, most participants noted the need to use existing in vivo toxicologic tests because of their greater familiarity and interpretability. For all types of toxicology tests, the best measures of nanoparticle dose need to be determined. Most participants agreed that a standard set of nanoparticles should be validated by laboratories worldwide and made available for benchmarking tests of other newly created nanoparticles. The group concluded that a battery of tests should be developed to uncover particularly hazardous properties. Given the large number of diverse materials, most participants favored a tiered approach. Over the long term, research aimed at developing a mechanistic understanding of the numerous characteristics that influence nanoparticle toxicity was deemed essential. Predicting the potential toxicity of emerging nanoparticles will require hypothesis-driven research that elucidates how physicochemical parameters influence toxic effects on biological systems. Research needs should be determined in the context of the current availability of testing methods for nanoscale particles. Finally, the group identified general policy and strategic opportunities to accelerate the development and implementation of testing protocols and ensure that the information generated is translated effectively for all stakeholders.",
keywords = "Nanomaterials, Nanoparticle, Nanotechnology, Nanotoxicology, Particle toxicology",
author = "Balbus, {John M.} and Maynard, {Andrew D.} and Colvin, {Vicki L.} and Vincent Castranova and Daston, {George P.} and Denison, {Richard A.} and Dreher, {Kevin L.} and Goering, {Peter L.} and Goldberg, {Alan M.} and Kulinowski, {Kristen M.} and Monteiro-Riviere, {Nancy A.} and G{\"u}nter Oberd{\"o}rster and Omenn, {Gilbert S.} and Pinkerton, {Kent E} and Ramos, {Kenneth S.} and Rest, {Kathleen M.} and Sass, {Jennifer B.} and Silbergeld, {Ellen K.} and Wong, {Brian A.}",
year = "2007",
month = "11",
doi = "10.1289/ehp.10327",
language = "English (US)",
volume = "115",
pages = "1654--1659",
journal = "Environmental Health Perspectives",
issn = "0091-6765",
publisher = "Public Health Services, US Dept of Health and Human Services",
number = "11",

}

TY - JOUR

T1 - Meeting report

T2 - Hazard assessment for nanoparticles-report from an interdisciplinary workshop

AU - Balbus, John M.

AU - Maynard, Andrew D.

AU - Colvin, Vicki L.

AU - Castranova, Vincent

AU - Daston, George P.

AU - Denison, Richard A.

AU - Dreher, Kevin L.

AU - Goering, Peter L.

AU - Goldberg, Alan M.

AU - Kulinowski, Kristen M.

AU - Monteiro-Riviere, Nancy A.

AU - Oberdörster, Günter

AU - Omenn, Gilbert S.

AU - Pinkerton, Kent E

AU - Ramos, Kenneth S.

AU - Rest, Kathleen M.

AU - Sass, Jennifer B.

AU - Silbergeld, Ellen K.

AU - Wong, Brian A.

PY - 2007/11

Y1 - 2007/11

N2 - In this report we present the findings from a nanotoxicology workshop held 6-7 April 2006 at the Woodrow Wilson International Center for Scholars in Washington, DC. Over 2 days, 26 scientists from government, academia, industry, and nonprofit organizations addressed two specific questions: what information is needed to understand the human health impact of engineered nanoparticles and how is this information best obtained? To assess hazards of nanoparticles in the near-term, most participants noted the need to use existing in vivo toxicologic tests because of their greater familiarity and interpretability. For all types of toxicology tests, the best measures of nanoparticle dose need to be determined. Most participants agreed that a standard set of nanoparticles should be validated by laboratories worldwide and made available for benchmarking tests of other newly created nanoparticles. The group concluded that a battery of tests should be developed to uncover particularly hazardous properties. Given the large number of diverse materials, most participants favored a tiered approach. Over the long term, research aimed at developing a mechanistic understanding of the numerous characteristics that influence nanoparticle toxicity was deemed essential. Predicting the potential toxicity of emerging nanoparticles will require hypothesis-driven research that elucidates how physicochemical parameters influence toxic effects on biological systems. Research needs should be determined in the context of the current availability of testing methods for nanoscale particles. Finally, the group identified general policy and strategic opportunities to accelerate the development and implementation of testing protocols and ensure that the information generated is translated effectively for all stakeholders.

AB - In this report we present the findings from a nanotoxicology workshop held 6-7 April 2006 at the Woodrow Wilson International Center for Scholars in Washington, DC. Over 2 days, 26 scientists from government, academia, industry, and nonprofit organizations addressed two specific questions: what information is needed to understand the human health impact of engineered nanoparticles and how is this information best obtained? To assess hazards of nanoparticles in the near-term, most participants noted the need to use existing in vivo toxicologic tests because of their greater familiarity and interpretability. For all types of toxicology tests, the best measures of nanoparticle dose need to be determined. Most participants agreed that a standard set of nanoparticles should be validated by laboratories worldwide and made available for benchmarking tests of other newly created nanoparticles. The group concluded that a battery of tests should be developed to uncover particularly hazardous properties. Given the large number of diverse materials, most participants favored a tiered approach. Over the long term, research aimed at developing a mechanistic understanding of the numerous characteristics that influence nanoparticle toxicity was deemed essential. Predicting the potential toxicity of emerging nanoparticles will require hypothesis-driven research that elucidates how physicochemical parameters influence toxic effects on biological systems. Research needs should be determined in the context of the current availability of testing methods for nanoscale particles. Finally, the group identified general policy and strategic opportunities to accelerate the development and implementation of testing protocols and ensure that the information generated is translated effectively for all stakeholders.

KW - Nanomaterials

KW - Nanoparticle

KW - Nanotechnology

KW - Nanotoxicology

KW - Particle toxicology

UR - http://www.scopus.com/inward/record.url?scp=38449088295&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38449088295&partnerID=8YFLogxK

U2 - 10.1289/ehp.10327

DO - 10.1289/ehp.10327

M3 - Article

C2 - 18007999

AN - SCOPUS:38449088295

VL - 115

SP - 1654

EP - 1659

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

SN - 0091-6765

IS - 11

ER -