Medium latency stretch reflexes in young-onset Parkinson's disease and MPTP-induced parkinsonism

B. R. Bloem, D. J. Beckley, J. G. van Dijk, A. H. Zwinderman, M. P. Remler, J. W. Langston, R. A C Roos

Research output: Contribution to journalArticle

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Abstract

It is still unclear why components of the phasic stretch reflex are increased in Parkinson's disease (PD). To study the role of aging, we assessed medium latency (ML) stretch reflexes in 19 Parkinson patients (8 with young-onset PD, 11 with late-onset PD) and 23 normal subjects (10 young, 13 old). To assess the contribution of supraspinal dopaminergic influences, we also studied 5 young parkinsonian patients with a selective central dopamine deficiency induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). ML responses were recorded from the medial gastrocnemius muscle which was stretched by 4° toe-up rotations of a platform upon which subjects were standing. ML responses were significantly enhanced in late-onset patients compared with older controls. In contrast, ML responses did not differ between young-onset patients and young controls. This observation could be attributed to the significantly different influence of age on ML-amplitudes in patients and controls. Thus, ML-amplitudes declined with age in controls, whereas they increased with age in PD possibly because older patients were more severely affected than younger patients. Thus, the difference between young-onset and late-onset PD seems to be related to the opposite effects of increasing age and disease severity in patients and controls. ML-amplitudes did not differ between patients with MPTP-induced parkinsonism, patients with young-onset PD and controls, suggesting that supraspinal dopaminergic systems are not critically involved in control of ML responses. This result also indicates that the severity effect in PD may be related to disruption of non-dopaminergic pathways which occurs in late-onset, but not young-onset patients. In conclusion, we postulate that lesions in non-dopaminergic systems in older Parkinson patients contribute to enhancement of ML responses, and possibly other late occurring stretch reflexes as well.

Original languageEnglish (US)
Pages (from-to)52-58
Number of pages7
JournalJournal of the Neurological Sciences
Volume123
Issue number1-2
DOIs
StatePublished - 1994

Fingerprint

Stretch Reflex
Parkinsonian Disorders
Parkinson Disease
Reaction Time
4-phenyl-1,2,3,6-tetrahydropyridine
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Toes
Dopamine
Skeletal Muscle

Keywords

  • Aging
  • Dopamine
  • MPTP
  • Parkinson's disease
  • Posture
  • Stretch reflex

ASJC Scopus subject areas

  • Aging
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

Cite this

Bloem, B. R., Beckley, D. J., van Dijk, J. G., Zwinderman, A. H., Remler, M. P., Langston, J. W., & Roos, R. A. C. (1994). Medium latency stretch reflexes in young-onset Parkinson's disease and MPTP-induced parkinsonism. Journal of the Neurological Sciences, 123(1-2), 52-58. https://doi.org/10.1016/0022-510X(94)90203-8

Medium latency stretch reflexes in young-onset Parkinson's disease and MPTP-induced parkinsonism. / Bloem, B. R.; Beckley, D. J.; van Dijk, J. G.; Zwinderman, A. H.; Remler, M. P.; Langston, J. W.; Roos, R. A C.

In: Journal of the Neurological Sciences, Vol. 123, No. 1-2, 1994, p. 52-58.

Research output: Contribution to journalArticle

Bloem, BR, Beckley, DJ, van Dijk, JG, Zwinderman, AH, Remler, MP, Langston, JW & Roos, RAC 1994, 'Medium latency stretch reflexes in young-onset Parkinson's disease and MPTP-induced parkinsonism', Journal of the Neurological Sciences, vol. 123, no. 1-2, pp. 52-58. https://doi.org/10.1016/0022-510X(94)90203-8
Bloem, B. R. ; Beckley, D. J. ; van Dijk, J. G. ; Zwinderman, A. H. ; Remler, M. P. ; Langston, J. W. ; Roos, R. A C. / Medium latency stretch reflexes in young-onset Parkinson's disease and MPTP-induced parkinsonism. In: Journal of the Neurological Sciences. 1994 ; Vol. 123, No. 1-2. pp. 52-58.
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