Abstract
Mediators of immune glomerular injury may be divided into primary ana secondary. Primary mediators include antibody and T cells and secondary include complement, infiltrating inflammatory cells, such as neutrophils, monocytes/macrophages and platelets, coagulation system, resident glomerular cells including mesangial, endothelial and epithelial cells, reactive oxygen metabolites, eicosanoids, proteolytic enzymes and a host of cytokines. Following initiation of immune glomerular injury with primary mediators, which in most cases is antibody, a complex set of interactions involving some or all of the secondary mediators occurs in the glomerulus, ultimately leading to the clinical manifestations of glomerular injury. The precise sequence and the mechanisms of these interactions are not fully defined but are under intense study. The identity of the putative antigens and why and how an autoimmune response develops are also not fully known.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 324-336 |
| Number of pages | 13 |
| Journal | American Journal of Nephrology |
| Volume | 13 |
| Issue number | 5 |
| State | Published - 1993 |
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Keywords
- Antibody
- Autoantibody
- Complement
- Cytokines
- Eicosanoids
- Glomerular cells
- Glomerular injury
- Glomerulonephritis
- Heymann nephritis
- Immune injury
ASJC Scopus subject areas
- Nephrology
Cite this
Mediators of immune glomerular injury. / Makker, Sudesh P.
In: American Journal of Nephrology, Vol. 13, No. 5, 1993, p. 324-336.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mediators of immune glomerular injury
AU - Makker, Sudesh P
PY - 1993
Y1 - 1993
N2 - Mediators of immune glomerular injury may be divided into primary ana secondary. Primary mediators include antibody and T cells and secondary include complement, infiltrating inflammatory cells, such as neutrophils, monocytes/macrophages and platelets, coagulation system, resident glomerular cells including mesangial, endothelial and epithelial cells, reactive oxygen metabolites, eicosanoids, proteolytic enzymes and a host of cytokines. Following initiation of immune glomerular injury with primary mediators, which in most cases is antibody, a complex set of interactions involving some or all of the secondary mediators occurs in the glomerulus, ultimately leading to the clinical manifestations of glomerular injury. The precise sequence and the mechanisms of these interactions are not fully defined but are under intense study. The identity of the putative antigens and why and how an autoimmune response develops are also not fully known.
AB - Mediators of immune glomerular injury may be divided into primary ana secondary. Primary mediators include antibody and T cells and secondary include complement, infiltrating inflammatory cells, such as neutrophils, monocytes/macrophages and platelets, coagulation system, resident glomerular cells including mesangial, endothelial and epithelial cells, reactive oxygen metabolites, eicosanoids, proteolytic enzymes and a host of cytokines. Following initiation of immune glomerular injury with primary mediators, which in most cases is antibody, a complex set of interactions involving some or all of the secondary mediators occurs in the glomerulus, ultimately leading to the clinical manifestations of glomerular injury. The precise sequence and the mechanisms of these interactions are not fully defined but are under intense study. The identity of the putative antigens and why and how an autoimmune response develops are also not fully known.
KW - Antibody
KW - Autoantibody
KW - Complement
KW - Cytokines
KW - Eicosanoids
KW - Glomerular cells
KW - Glomerular injury
KW - Glomerulonephritis
KW - Heymann nephritis
KW - Immune injury
UR - http://www.scopus.com/inward/record.url?scp=0027730872&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027730872&partnerID=8YFLogxK
M3 - Article
C2 - 8116685
AN - SCOPUS:0027730872
VL - 13
SP - 324
EP - 336
JO - American Journal of Nephrology
JF - American Journal of Nephrology
SN - 0250-8095
IS - 5
ER -