Medial temporal lobe contributions to cued retrieval of items and contexts

Deborah E. Hannula, Laura A. Libby, Andrew P. Yonelinas, Charan Ranganath

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Several models have proposed that different regions of the medial temporal lobes contribute to different aspects of episodic memory. For instance, according to one view, the perirhinal cortex represents specific items, parahippocampal cortex represents information regarding the context in which these items were encountered, and the hippocampus represents item-context bindings. Here, we used event-related functional magnetic resonance imaging (fMRI) to test a specific prediction of this model-namely, that successful retrieval of items from context cues will elicit perirhinal recruitment and that successful retrieval of contexts from item cues will elicit parahippocampal cortex recruitment. Retrieval of the bound representation in either case was expected to elicit hippocampal engagement. To test these predictions, we had participants study several item-context pairs (i.e., pictures of objects and scenes, respectively), and then had them attempt to recall items from associated context cues and contexts from associated item cues during a scanned retrieval session. Results based on both univariate and multivariate analyses confirmed a role for hippocampus in content-general relational memory retrieval, and a role for parahippocampal cortex in successful retrieval of contexts from item cues. However, we also found that activity differences in perirhinal cortex were correlated with successful cued recall for both items and contexts. These findings provide partial support for the above predictions and are discussed with respect to several models of medial temporal lobe function.

Original languageEnglish (US)
Pages (from-to)2322-2332
Number of pages11
JournalNeuropsychologia
Volume51
Issue number12
DOIs
StatePublished - Oct 2013

Fingerprint

Temporal Lobe
Cues
Hippocampus
Episodic Memory
Multivariate Analysis
Magnetic Resonance Imaging
Medial Temporal Lobe
Cortex
Perirhinal Cortex

Keywords

  • Episodic memory
  • Hippocampus
  • Medial temporal lobe
  • Parahippocampal cortex
  • Perirhinal cortex
  • Retrieval

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology
  • Arts and Humanities (miscellaneous)

Cite this

Medial temporal lobe contributions to cued retrieval of items and contexts. / Hannula, Deborah E.; Libby, Laura A.; Yonelinas, Andrew P.; Ranganath, Charan.

In: Neuropsychologia, Vol. 51, No. 12, 10.2013, p. 2322-2332.

Research output: Contribution to journalArticle

Hannula, DE, Libby, LA, Yonelinas, AP & Ranganath, C 2013, 'Medial temporal lobe contributions to cued retrieval of items and contexts', Neuropsychologia, vol. 51, no. 12, pp. 2322-2332. https://doi.org/10.1016/j.neuropsychologia.2013.02.011
Hannula, Deborah E. ; Libby, Laura A. ; Yonelinas, Andrew P. ; Ranganath, Charan. / Medial temporal lobe contributions to cued retrieval of items and contexts. In: Neuropsychologia. 2013 ; Vol. 51, No. 12. pp. 2322-2332.
@article{31ada32edb16464691bb8b25b41a7616,
title = "Medial temporal lobe contributions to cued retrieval of items and contexts",
abstract = "Several models have proposed that different regions of the medial temporal lobes contribute to different aspects of episodic memory. For instance, according to one view, the perirhinal cortex represents specific items, parahippocampal cortex represents information regarding the context in which these items were encountered, and the hippocampus represents item-context bindings. Here, we used event-related functional magnetic resonance imaging (fMRI) to test a specific prediction of this model-namely, that successful retrieval of items from context cues will elicit perirhinal recruitment and that successful retrieval of contexts from item cues will elicit parahippocampal cortex recruitment. Retrieval of the bound representation in either case was expected to elicit hippocampal engagement. To test these predictions, we had participants study several item-context pairs (i.e., pictures of objects and scenes, respectively), and then had them attempt to recall items from associated context cues and contexts from associated item cues during a scanned retrieval session. Results based on both univariate and multivariate analyses confirmed a role for hippocampus in content-general relational memory retrieval, and a role for parahippocampal cortex in successful retrieval of contexts from item cues. However, we also found that activity differences in perirhinal cortex were correlated with successful cued recall for both items and contexts. These findings provide partial support for the above predictions and are discussed with respect to several models of medial temporal lobe function.",
keywords = "Episodic memory, Hippocampus, Medial temporal lobe, Parahippocampal cortex, Perirhinal cortex, Retrieval",
author = "Hannula, {Deborah E.} and Libby, {Laura A.} and Yonelinas, {Andrew P.} and Charan Ranganath",
year = "2013",
month = "10",
doi = "10.1016/j.neuropsychologia.2013.02.011",
language = "English (US)",
volume = "51",
pages = "2322--2332",
journal = "Neuropsychologia",
issn = "0028-3932",
publisher = "Elsevier Limited",
number = "12",

}

TY - JOUR

T1 - Medial temporal lobe contributions to cued retrieval of items and contexts

AU - Hannula, Deborah E.

AU - Libby, Laura A.

AU - Yonelinas, Andrew P.

AU - Ranganath, Charan

PY - 2013/10

Y1 - 2013/10

N2 - Several models have proposed that different regions of the medial temporal lobes contribute to different aspects of episodic memory. For instance, according to one view, the perirhinal cortex represents specific items, parahippocampal cortex represents information regarding the context in which these items were encountered, and the hippocampus represents item-context bindings. Here, we used event-related functional magnetic resonance imaging (fMRI) to test a specific prediction of this model-namely, that successful retrieval of items from context cues will elicit perirhinal recruitment and that successful retrieval of contexts from item cues will elicit parahippocampal cortex recruitment. Retrieval of the bound representation in either case was expected to elicit hippocampal engagement. To test these predictions, we had participants study several item-context pairs (i.e., pictures of objects and scenes, respectively), and then had them attempt to recall items from associated context cues and contexts from associated item cues during a scanned retrieval session. Results based on both univariate and multivariate analyses confirmed a role for hippocampus in content-general relational memory retrieval, and a role for parahippocampal cortex in successful retrieval of contexts from item cues. However, we also found that activity differences in perirhinal cortex were correlated with successful cued recall for both items and contexts. These findings provide partial support for the above predictions and are discussed with respect to several models of medial temporal lobe function.

AB - Several models have proposed that different regions of the medial temporal lobes contribute to different aspects of episodic memory. For instance, according to one view, the perirhinal cortex represents specific items, parahippocampal cortex represents information regarding the context in which these items were encountered, and the hippocampus represents item-context bindings. Here, we used event-related functional magnetic resonance imaging (fMRI) to test a specific prediction of this model-namely, that successful retrieval of items from context cues will elicit perirhinal recruitment and that successful retrieval of contexts from item cues will elicit parahippocampal cortex recruitment. Retrieval of the bound representation in either case was expected to elicit hippocampal engagement. To test these predictions, we had participants study several item-context pairs (i.e., pictures of objects and scenes, respectively), and then had them attempt to recall items from associated context cues and contexts from associated item cues during a scanned retrieval session. Results based on both univariate and multivariate analyses confirmed a role for hippocampus in content-general relational memory retrieval, and a role for parahippocampal cortex in successful retrieval of contexts from item cues. However, we also found that activity differences in perirhinal cortex were correlated with successful cued recall for both items and contexts. These findings provide partial support for the above predictions and are discussed with respect to several models of medial temporal lobe function.

KW - Episodic memory

KW - Hippocampus

KW - Medial temporal lobe

KW - Parahippocampal cortex

KW - Perirhinal cortex

KW - Retrieval

UR - http://www.scopus.com/inward/record.url?scp=84886094600&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84886094600&partnerID=8YFLogxK

U2 - 10.1016/j.neuropsychologia.2013.02.011

DO - 10.1016/j.neuropsychologia.2013.02.011

M3 - Article

VL - 51

SP - 2322

EP - 2332

JO - Neuropsychologia

JF - Neuropsychologia

SN - 0028-3932

IS - 12

ER -