Medial temporal lobe coding of item and spatial information during relational binding in working memory

Laura A. Libby, Deborah E. Hannula, Charan Ranganath

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Several models have proposed that different medial temporal lobe (MTL) regions represent different kinds of information in the service of long-term memory. For instance, it has been proposed that perirhinal cortex (PRC), parahippocampal cortex (PHC), and hippocampus differentially support long-term memory for item information, spatial context, and item–context relations present during an event, respectively. Recent evidence has indicated that, in addition to long-term memory, MTL subregions may similarly contribute to processes that support the retention of complex spatial arrangements of objects across short delays. Here, we used functional magnetic resonance imaging and multivoxel pattern similarity analysis to investigate the extent to which human MTL regions independently code for object and spatial information, as well as the conjunction of this information, during working memory encoding and active maintenance. Voxel activity patterns in PRC, temporopolar cortex, and amygdala carried information about individual objects, whereas activity patterns in the PHC and posterior hippocampus carried information about the configuration of spatial locations that was to be remembered. Additionally, the integrity of multivoxel patterns in the right anterior hippocampus across encoding and delay periods was predictive of accurate short-term memory for object–location relationships. These results are consistent with parallel processing of item and spatial context information by PRC and PHC, respectively, and the binding of item and context by the hippocampus.

Original languageEnglish (US)
Pages (from-to)14233-14242
Number of pages10
JournalJournal of Neuroscience
Volume34
Issue number43
DOIs
StatePublished - Oct 22 2014
Externally publishedYes

Fingerprint

Temporal Lobe
Short-Term Memory
Long-Term Memory
Hippocampus
Information Services
Amygdala
Maintenance
Magnetic Resonance Imaging
Perirhinal Cortex

Keywords

  • FMRI
  • Hippocampus
  • Multivoxel pattern
  • Parahippocampal
  • Perirhinal
  • Working memory

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

Medial temporal lobe coding of item and spatial information during relational binding in working memory. / Libby, Laura A.; Hannula, Deborah E.; Ranganath, Charan.

In: Journal of Neuroscience, Vol. 34, No. 43, 22.10.2014, p. 14233-14242.

Research output: Contribution to journalArticle

Libby, Laura A. ; Hannula, Deborah E. ; Ranganath, Charan. / Medial temporal lobe coding of item and spatial information during relational binding in working memory. In: Journal of Neuroscience. 2014 ; Vol. 34, No. 43. pp. 14233-14242.
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