Mechanochemical delivery and dynamic tracking of fluorescent quantum dots in the cytoplasm and nucleus of living Cells

Kyungsuk Yum, Sungsoo Na, Yang Kevin Xiang, Ning Wang, Min Feng Yu

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

Studying molecular dynamics inside living cells is a major but highly rewarding challenge in cell biology. We present a nanoscale mechanochemical method to deliver fluorescent quantum dots (QDs) into living cells, using a membrane-penetrating nanoneedle. We demonstrate the selective delivery of monodispersed QDs into the cytoplasm and the nucleus of living cells and the tracking of the delivered QDs inside the cells. The ability to deliver and track QDs may invite unconventional strategies for studying biological processes and biophysical properties in living cells with spatial and temporal precision, potentially with molecular resolution.

Original languageEnglish (US)
Pages (from-to)2193-2198
Number of pages6
JournalNano Letters
Volume9
Issue number5
DOIs
StatePublished - May 13 2009
Externally publishedYes

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cytoplasm
Semiconductor quantum dots
delivery
quantum dots
Cells
nuclei
Nanoneedles
Cytology
Molecular dynamics
Membranes
molecular dynamics
membranes
cells

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanical Engineering

Cite this

Mechanochemical delivery and dynamic tracking of fluorescent quantum dots in the cytoplasm and nucleus of living Cells. / Yum, Kyungsuk; Na, Sungsoo; Xiang, Yang Kevin; Wang, Ning; Yu, Min Feng.

In: Nano Letters, Vol. 9, No. 5, 13.05.2009, p. 2193-2198.

Research output: Contribution to journalArticle

Yum, Kyungsuk ; Na, Sungsoo ; Xiang, Yang Kevin ; Wang, Ning ; Yu, Min Feng. / Mechanochemical delivery and dynamic tracking of fluorescent quantum dots in the cytoplasm and nucleus of living Cells. In: Nano Letters. 2009 ; Vol. 9, No. 5. pp. 2193-2198.
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