Mechanistic rationales for targeting interleukin-17A in spondyloarthritis

Siba P Raychaudhuri, Smriti K. Raychaudhuri

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

The term spondyloarthritis (SpA) is used to describe a group of inflammatory autoimmune diseases, including ankylosing spondylitis and psoriatic arthritis, with common genetic risk factors and clinical features. SpA is clinically distinct from rheumatoid arthritis and typically affects the spine, sacroiliac joints, entheses, and, less commonly, peripheral joints. Although the pathogenesis of SpA is not fully understood, recent findings have identified the interleukin (IL)-17 pathway as a key mediator of disease pathogenesis. Clinical evidence for the efficacy of IL-17A inhibition by biologic agents was initially shown in patients with chronic plaque psoriasis, another autoimmune disease mediated by the IL-17 pathway. Subsequently, similar positive efficacy for inhibition of IL-17A was seen in patients with ankylosing spondylitis and psoriatic arthritis. Inhibition of IL-17A may also improve cardiovascular and metabolic comorbidities often found in patients with SpA because studies have linked these disorders to the IL-17 pathway. In this review, we will examine key preclinical studies that demonstrated the mechanistic role of IL-17A in the development SpA and discuss how these observations were translated into clinical practice.

Original languageEnglish (US)
Article number51
JournalArthritis Research and Therapy
Volume19
Issue number1
DOIs
StatePublished - Mar 8 2017

Keywords

  • Ankylosing spondylitis
  • Clinical practice
  • IL-17A inhibition
  • Interleukin-17
  • Preclinical studies
  • Psoriatic arthritis
  • Review
  • Spondyloarthritis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology

Fingerprint Dive into the research topics of 'Mechanistic rationales for targeting interleukin-17A in spondyloarthritis'. Together they form a unique fingerprint.

Cite this