Mechanistic aspects of the DNA strand exchange activity of E. coli recA protein

Stephen C. Kowalczykowski

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29 Scopus citations

Abstract

The recA protein Escherichia coli catalyses a reaction that is unique in nucleic acid enzymology: it can promote the exchange of single strands of DNA between different duplex DNA molecules with sequence complementarity. The DNA strand exchange reaction comprises several distinct biochemical steps, requires ATP hydrolysis, and is stimulated by the E. coli single-stranded DNA binding (SSB) protein. The molecular mechanism of each of these steps is discussed.

Original languageEnglish (US)
Pages (from-to)141-145
Number of pages5
JournalTrends in Biochemical Sciences
Volume12
Issue numberC
DOIs
StatePublished - 1987
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry

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