Mechanistic aspects of the DNA strand exchange activity of E. coli recA protein

Stephen C. Kowalczykowski

Research output: Contribution to journalArticle

29 Scopus citations


The recA protein Escherichia coli catalyses a reaction that is unique in nucleic acid enzymology: it can promote the exchange of single strands of DNA between different duplex DNA molecules with sequence complementarity. The DNA strand exchange reaction comprises several distinct biochemical steps, requires ATP hydrolysis, and is stimulated by the E. coli single-stranded DNA binding (SSB) protein. The molecular mechanism of each of these steps is discussed.

Original languageEnglish (US)
Pages (from-to)141-145
Number of pages5
JournalTrends in Biochemical Sciences
Issue numberC
StatePublished - 1987
Externally publishedYes


ASJC Scopus subject areas

  • Biochemistry

Cite this