Mechanistic aspects of the DNA strand exchange activity of E. coli recA protein

Stephen C. Kowalczykowski

doi:10.1016/0968-0004(87)90070-3

Mechanistic aspects of the DNA strand exchange activity of E. coli recA protein

Stephen C. Kowalczykowski

Research output: Contribution to journal › Article

29 Scopus citations

Abstract

The recA protein Escherichia coli catalyses a reaction that is unique in nucleic acid enzymology: it can promote the exchange of single strands of DNA between different duplex DNA molecules with sequence complementarity. The DNA strand exchange reaction comprises several distinct biochemical steps, requires ATP hydrolysis, and is stimulated by the E. coli single-stranded DNA binding (SSB) protein. The molecular mechanism of each of these steps is discussed.

Original language	English (US)
Pages (from-to)	141-145
Number of pages	5
Journal	Trends in Biochemical Sciences
Volume	12
Issue number	C
DOIs	https://doi.org/10.1016/0968-0004(87)90070-3
State	Published - 1987
Externally published	Yes

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ASJC Scopus subject areas

Biochemistry

Cite this

Kowalczykowski, S. C. (1987). Mechanistic aspects of the DNA strand exchange activity of E. coli recA protein. Trends in Biochemical Sciences, 12(C), 141-145. https://doi.org/10.1016/0968-0004(87)90070-3

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Access to Document

10.1016/0968-0004(87)90070-3