Mechanisms underlying epileptiform burst discharge

Research output: Contribution to journalArticle

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Abstract

Studies of hyperexcitable cells in alumina-gel and penicillin epileptogenic foci suggest that epileptic neurons have intrinsic burst-generating properties. The burst mechanism may be released or triggered by a number of extrinsic factors which disrupt the normal depolarizing-hyperpolarizing balance. This paper presents the hypothesis that the most important influence for burst discharge is influx of calcium ions. This excitatory effect is modulated by synaptic inputs, hyperpolarizing conductances, cell morphology and membrane characteristics, and the extracellular milieu. The hypothesis incorporates fndings from both penicillin and alumin models of epilepsy and provides experimentally testable concepts for further investigation.

Original languageEnglish (US)
Pages (from-to)95-107
Number of pages13
JournalAnnals of Neurology
Volume7
Issue number2
StatePublished - 1980
Externally publishedYes

Fingerprint

Penicillins
Aluminum Oxide
Epilepsy
Gels
Cell Membrane
Ions
Calcium
Neurons

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Mechanisms underlying epileptiform burst discharge. / Schwartzkroin, Philip A; Wyler, A. R.

In: Annals of Neurology, Vol. 7, No. 2, 1980, p. 95-107.

Research output: Contribution to journalArticle

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