Abstract
Studies of hyperexcitable cells in alumina-gel and penicillin epileptogenic foci suggest that epileptic neurons have intrinsic burst-generating properties. The burst mechanism may be released or triggered by a number of extrinsic factors which disrupt the normal depolarizing-hyperpolarizing balance. This paper presents the hypothesis that the most important influence for burst discharge is influx of calcium ions. This excitatory effect is modulated by synaptic inputs, hyperpolarizing conductances, cell morphology and membrane characteristics, and the extracellular milieu. The hypothesis incorporates fndings from both penicillin and alumin models of epilepsy and provides experimentally testable concepts for further investigation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 95-107 |
| Number of pages | 13 |
| Journal | Annals of Neurology |
| Volume | 7 |
| Issue number | 2 |
| State | Published - 1980 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Mechanisms underlying epileptiform burst discharge. / Schwartzkroin, Philip A; Wyler, A. R.
In: Annals of Neurology, Vol. 7, No. 2, 1980, p. 95-107.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mechanisms underlying epileptiform burst discharge
AU - Schwartzkroin, Philip A
AU - Wyler, A. R.
PY - 1980
Y1 - 1980
N2 - Studies of hyperexcitable cells in alumina-gel and penicillin epileptogenic foci suggest that epileptic neurons have intrinsic burst-generating properties. The burst mechanism may be released or triggered by a number of extrinsic factors which disrupt the normal depolarizing-hyperpolarizing balance. This paper presents the hypothesis that the most important influence for burst discharge is influx of calcium ions. This excitatory effect is modulated by synaptic inputs, hyperpolarizing conductances, cell morphology and membrane characteristics, and the extracellular milieu. The hypothesis incorporates fndings from both penicillin and alumin models of epilepsy and provides experimentally testable concepts for further investigation.
AB - Studies of hyperexcitable cells in alumina-gel and penicillin epileptogenic foci suggest that epileptic neurons have intrinsic burst-generating properties. The burst mechanism may be released or triggered by a number of extrinsic factors which disrupt the normal depolarizing-hyperpolarizing balance. This paper presents the hypothesis that the most important influence for burst discharge is influx of calcium ions. This excitatory effect is modulated by synaptic inputs, hyperpolarizing conductances, cell morphology and membrane characteristics, and the extracellular milieu. The hypothesis incorporates fndings from both penicillin and alumin models of epilepsy and provides experimentally testable concepts for further investigation.
UR - http://www.scopus.com/inward/record.url?scp=0018844533&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018844533&partnerID=8YFLogxK
M3 - Article
VL - 7
SP - 95
EP - 107
JO - Annals of Neurology
JF - Annals of Neurology
SN - 0364-5134
IS - 2
ER -