Mechanisms of Stroke Recovery

Kwan Ng, S. T. Carmichael

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Stroke marks the beginning of a cascade of molecular and cellular processes that allow for neural repair and recovery. Stroke induces changes in the excitability of neuronal circuits in peri-infarct cortex that underlie the process of remapping motor and sensory function. Axonal sprouting occurs in tissue adjacent to the stroke and its connected areas. Stroke cues support the association of angiogenic vessels with the migration of newborn neurons into the peri-infarct area in a neurovascular unit. Neurogenesis, angiogenesis, and axonal sprouting support neurologic recovery after stroke. This chapter focuses on the fundamental mechanisms and timing of stroke recovery.

Original languageEnglish (US)
Title of host publicationPrimer on Cerebrovascular Diseases
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages171-174
Number of pages4
ISBN (Print)9780128030585
DOIs
StatePublished - Mar 7 2017
Externally publishedYes

Keywords

  • Angiogenesis
  • Axonal sprouting
  • Neural repair
  • Neurogenesis
  • Neurorehabilitation
  • Neurovascular unit
  • Oligodendrogenesis
  • Stroke

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Ng, K., & Carmichael, S. T. (2017). Mechanisms of Stroke Recovery. In Primer on Cerebrovascular Diseases: Second Edition (pp. 171-174). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-803058-5.00035-7