Mechanisms of spindle positioning

Francis J. McNally

Research output: Contribution to journalArticlepeer-review

122 Scopus citations


Accurate positioning of spindles is essential for asymmetric mitotic and meiotic cell divisions that are crucial for animal development and oocyte maturation, respectively. The predominant model for spindle positioning, termed "cortical pulling," involves attachment of the microtubulebased motor cytoplasmic dynein to the cortex, where it exerts a pulling force on microtubules that extend from the spindle poles to the cell cortex, thereby displacing the spindle. Recent studies have addressed important details of the cortical pulling mechanism and have revealed alternative mechanisms that may be used when microtubules do not extend from the spindle to the cortex.

Original languageEnglish (US)
Pages (from-to)131-140
Number of pages10
JournalJournal of Cell Biology
Issue number2
StatePublished - Jan 2013

ASJC Scopus subject areas

  • Cell Biology


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