Mechanisms of resistance to the juvenoid methoprene in the house fly Musca domestica L

Bruce D. Hammock, Susanne M. Mumby, Philip W. Lee

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The mechanisms of resistance and cross resistance to the juvenoids methoprene and R-20458 in the house fly, Musca domestica, were examined. Radiolabeled methoprene was found to be metabolized faster in resistant and cross-resistant house fly larvae than in susceptible larvae, and methoprene and R-20458 penetrated more slowly into larvae of the resistant strain. In vivo and in vitro metabolism of methoprene was largely by oxidative pathways followed by conjugation in all strains examined, and little or no ester change of methoprene was noted in vitro. In vitro oxidative metabolism of methoprene, R-20458, juvenile hormone I, and several model substrates was higher in resistant and cross-resistant larvae than in susceptible larvae. Juvenoid functionalities susceptible to metabolic attack by resistant strains are indicated.

Original languageEnglish (US)
Pages (from-to)261-272
Number of pages12
JournalPesticide Biochemistry and Physiology
Volume7
Issue number3
DOIs
StatePublished - 1977

Fingerprint

Methoprene
Houseflies
methoprene
juvenile hormone analogs
Musca domestica
ethylphenylepoxygeranyl ether
resistance mechanisms
Diptera
Larva
larvae
Metabolism
cross resistance
aerobiosis
juvenile hormones
insect larvae
Esters
esters
metabolism
Substrates

ASJC Scopus subject areas

  • Agronomy and Crop Science
  • Biochemistry
  • Physiology

Cite this

Mechanisms of resistance to the juvenoid methoprene in the house fly Musca domestica L. / Hammock, Bruce D.; Mumby, Susanne M.; Lee, Philip W.

In: Pesticide Biochemistry and Physiology, Vol. 7, No. 3, 1977, p. 261-272.

Research output: Contribution to journalArticle

Hammock, Bruce D. ; Mumby, Susanne M. ; Lee, Philip W. / Mechanisms of resistance to the juvenoid methoprene in the house fly Musca domestica L. In: Pesticide Biochemistry and Physiology. 1977 ; Vol. 7, No. 3. pp. 261-272.
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