Mechanisms of postsynaptic localization of AMPA-type glutamate receptors and their regulation during long-term potentiation

Olivia R. Buonarati, Erik A. Hammes, Jake F. Watson, Ingo H. Greger, Johannes W Hell

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

l-Glutamate is the main excitatory neurotransmitter in the brain, with postsynaptic responses to its release predominantly mediated by AMPA-type glutamate receptors (AMPARs). A critical component of synaptic plasticity involves changes in the number of responding postsynaptic receptors, which are dynamically recruited to and anchored at postsynaptic sites. Emerging findings continue to shed new light on molecular mechanisms that mediate AMPAR postsynaptic trafficking and localization. Accordingly, unconventional secretory trafficking of AMPARs occurs in dendrites, from the endoplasmic reticulum (ER) through the ER-Golgi intermediary compartment directly to recycling endosomes, independent of the Golgi apparatus. Upon exocytosis, AMPARs diffuse in the plasma membrane to reach the postsynaptic site, where they are trapped to contribute to transmission. This trapping occurs through a combination of both intracellular interactions, such as TARP (transmembrane AMPAR regulatory protein) binding to α-actinin-stabilized PSD-95, and extracellular interactions through the receptor amino-terminal domain. These anchoring mechanisms may facilitate precise receptor positioning with respect to glutamate release sites to enable efficient synaptic transmission.

Original languageEnglish (US)
JournalScience Signaling
Volume12
Issue number562
DOIs
StatePublished - Jan 1 2019

Fingerprint

alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
AMPA Receptors
Long-Term Potentiation
Glutamate Receptors
Endoplasmic Reticulum
Glutamic Acid
Actinin
Neuronal Plasticity
Endosomes
Exocytosis
Golgi Apparatus
Cell membranes
Dendrites
Protein Binding
Synaptic Transmission
Plasticity
Neurotransmitter Agents
Recycling
Brain
Cell Membrane

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Mechanisms of postsynaptic localization of AMPA-type glutamate receptors and their regulation during long-term potentiation. / Buonarati, Olivia R.; Hammes, Erik A.; Watson, Jake F.; Greger, Ingo H.; Hell, Johannes W.

In: Science Signaling, Vol. 12, No. 562, 01.01.2019.

Research output: Contribution to journalReview article

Buonarati, Olivia R. ; Hammes, Erik A. ; Watson, Jake F. ; Greger, Ingo H. ; Hell, Johannes W. / Mechanisms of postsynaptic localization of AMPA-type glutamate receptors and their regulation during long-term potentiation. In: Science Signaling. 2019 ; Vol. 12, No. 562.
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