Mechanisms of genetic instability revealed by analysis of yeast spindle pole body duplication

Heidi J. Chial, Mark Winey

Research output: Contribution to journalReview article

18 Scopus citations

Abstract

Aneuploidy and polyploidy are commonly observed in transformed cells. These states arise from failures during mitotic chromosome segregation, some of which can be traced to defects in the function or duplication of the centrosome. The centrosome is the organizing center for the mitotic spindle, and the equivalent organelle in the budding yeast, Saccharomyces cerevisiae, is the spindle pole body. We review how defects in spindle pole body duplication or function lead to genetic instability in yeast. There are several well documented instances of genetic instability in yeast that can be traced to the spindle pole body, all of which serve as models for genetic instability in transformed cells. (C) 1999 Editions scientifiques et medicales Elsevier SAS.

Original languageEnglish (US)
Pages (from-to)439-450
Number of pages12
JournalBiology of the Cell
Volume91
Issue number6
DOIs
StatePublished - Jan 1 1999
Externally publishedYes

Keywords

  • Aneuploidy
  • Genetic instability
  • Mitotic spindle
  • Spindle pole body

ASJC Scopus subject areas

  • Cell Biology

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