Mechanisms of Genetic Arrhythmias: From DNA to ECG

Ian W. Glaaser, Robert S. Kass, Colleen E Clancy

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

A precise balance of ionic currents underlies normal cardiac excitation and relaxation. Disruption of this equilibrium by genetic defects, polymorphisms, therapeutic intervention, and structural abnormalities can cause arrhythmogenic phenotypes leading to syncope, seizures, and sudden cardiac death. Congenital defects result in an unpredictable expression of phenotypes with variable penetrance, even within single families. Additionally, phenotypically opposite and overlapping cardiac arrhythmogenic syndromes can even stem from the same mutation. Accordingly, the relationship between genetic mutations and clinical syndromes is becoming increasingly complex.

Original languageEnglish (US)
Pages (from-to)259-270
Number of pages12
JournalProgress in Cardiovascular Diseases
Volume46
Issue number3
DOIs
StatePublished - Nov 2003
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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