Mechanisms of alloimmune tolerance associated with mixed chimerism induced by vascularized bone marrow transplants

Rajen Ramsamooj, Ramon Llull, Mayuri P. Patel, Kenneth R. Beko, Kirby S. Black, Charles W. Hewitt

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Rat limb allograft recipients represent surgically induced, immediately vascularized bone marrow transplant (VBMT) chimeras. The majority of these chimeras undergo tolerance while a minority develop graft versus host disease (GVHD). T-cell chimerism and associated mechanisms of cellular immune nonresponsiveness were investigated in tolerant VBMT chimeras. A strong correlation (p < 0.01) was observed between the clinical onset of GVHD and levels of donor T-cell chimerism approximating or greater than 50%. However, stable mixed chimerism was associated with tolerance. In conclusion, three major sequential mechanisms of immune nonresponsiveness were elucidated in tolerant VBMT chimeras over time and included development of nonspecific suppressor cells (which potentially represent natural suppressor cells), maturation of antigenspecific suppressor cell circuits, and eventually putative clonal inactivation.

Original languageEnglish (US)
Pages (from-to)683-693
Number of pages11
JournalCell Transplantation
Volume11
Issue number7
StatePublished - 2002

Keywords

  • Composite tissue limb allograft
  • Extremity transplant

ASJC Scopus subject areas

  • Cell Biology
  • Transplantation

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    Ramsamooj, R., Llull, R., Patel, M. P., Beko, K. R., Black, K. S., & Hewitt, C. W. (2002). Mechanisms of alloimmune tolerance associated with mixed chimerism induced by vascularized bone marrow transplants. Cell Transplantation, 11(7), 683-693.